Mitochondrial mutations and colorectal cancer prognosis
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Human mitochondrial DNA (mtDNA) is thought to be more prone to mutations than nuclear DNA, and mutations within this 16,569 base-pair genome have been reported in different types of cancers. Lièvre and colleagues have now identified a mutational 'hotspot' within the non-coding, displacement-loop (D-loop) region of the mitochondrial genome; their recent paper relates these findings to the clinicopathologic characteristics of a series of patients with colorectal cancer.
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