Review

Nature Clinical Practice Oncology (2005) 2, 82-89
doi:10.1038/ncponc0097  
Received 15 September 2004 | Accepted 6 January 2005

Therapy Insight: potential of statins for cancer chemoprevention and therapy

Matthew S Katz

Correspondence Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA

Email
 mskatz@partners.org

Statins are commonly prescribed to treat dyslipidemia and to prevent coronary artery disease, but studies also indicate their potential for cancer prevention. Preclinical data suggest pleiotropic antineoplastic effects of statins, but clinical data assessing cancer risk associated with statin use are conflicting. This review critically discusses the existing evidence highlighting the role of statins for cancer chemoprevention.

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