Mechanisms of Disease: prediction and prevention of breast cancer—cellular and molecular interactions
Anthony Howell*, Andrew H Sims, Kai Ren Ong, Michelle N Harvie, D Gareth R Evans and Robert B Clarke
Correspondence *CR-UK Dept of Medical Oncology, University of Manchester, Christie Hospital (NHS) Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK
Email maria.parker@christie-tr.nwest.nhs.uk
Breast cancer is a multifactorial condition, and changes in cellular biology are affected by a large number of variables known to affect an individual's susceptibility to this malignancy. Current risk prediction models are based on combinations of risk factors and have good predictive but low discriminatory power. Risk estimation might be improved by incorporating additional factors into risk prediction models, which will allow better determination of breast cancer risk and provide new targets for preventive therapies.
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