Research Highlights

Nature Clinical Practice Oncology (2005) 2, 603
doi:10.1038/ncponc0335  

Specific and sensitive detection of prostate cancer using urine sediment DNA

Carol Lovegrove

This article has no abstract so we have provided the first paragraph of the full text.

Treatment of prostate cancer can be curative but depends on early detection. Although prostate-specific antigen (PSA) is widely regarded as one of the best serum tumor markers, PSA level alone is neither sensitive nor specific enough for a definitive diagnosis, and transrectal biopsies are needed to confirm prostate cancer. A recent study has demonstrated that the detection of aberrant promoter methylation using quantitative methylation-specific polymerase chain reaction (QMSP) in urine sediment DNA offers potential as a specific, sensitive and noninvasive test for prostate cancer.

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