Induction of antitumor immunity by partial resection and combination adjuvant therapy
Carol Lovegrove
This article has no abstract so we have provided the first paragraph of the full text.
Resection of advanced solid tumors is rarely successful because there is a high degree of local recurrence and growth of previously undetectable micrometastases. Postsurgical adjuvant therapy (immunotherapy or chemotherapy) used in an attempt to destroy these residual cancer cells has met with limited success. Because of this, many patients with extensive disease are not considered candidates for surgery. Results from a recent animal study, however, suggest that, rather than being detrimental, partial debulking of solid tumors might actually elicit beneficial anti-tumor memory if followed by combination adjuvant therapy.
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