Can combined whole brain radiation therapy and radiosurgery improve the treatment of single brain metastases?
Jay S Loeffler
Correspondence Department of Radiation Oncology, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA
Email jloeffler@partners.org
This article has no abstract so we have provided the first paragraph of the full text.
Can aggressive therapy for a single brain metastasis improve survival for people who have systemic cancer? This question was partially resolved more than 10 years ago when two randomized trials showed that patients treated using both surgery and whole brain radiation therapy (WBRT) had improved survival rates compared with patients treated with WBRT alone.1, 2 A third trial, however, showed that patients who received combined WBRT and surgery did not have a survival advantage.3 Andrews et al. have more recently shown that combined radiosurgery and WBRT improved survival more than WBRT alone for patients who had a single, inoperable brain metastasis.
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