Table of contents
July 2008 Volume 4 No 7
Editorial
Neurology patients online: perceptions and reality
347doi:10.1038/ncpneuro0852 | Full Text | PDF (100K)
Research Highlights
TARDBP mutations implicated in the pathogenesis of ALS
348Baseline serum urate levels correlate with disease progression in PD
348Central obesity in middle age increases the risk of dementia later in life
348doi:10.1038/ncpneuro0814 | Full Text | PDF (103K)
Dopamine withdrawal leads to apathy in patients with PD
349Screening for early signs of autistic behaviors in ex-preterm infants
349doi:10.1038/ncpneuro0816 | Full Text | PDF (100K)
Role of the polyglutamine expansion in the pathogenesis of spinocerebellar ataxia type 1
350Intensive blood pressure reduction may reduce hematoma growth after ICH
351Practice Points
Evidence for long-term IVIg treatment of chronic inflammatory demyelinating polyradiculoneuropathy
352doi:10.1038/ncpneuro0788 | Full Text | PDF (129K)
Should patients with epilepsy be routinely screened for low bone mineral density?
354doi:10.1038/ncpneuro0822 | Full Text | PDF (126K)
Noninvasive mechanical ventilation in patients with myasthenic crisis
356doi:10.1038/ncpneuro0793 | Full Text | PDF (125K)
Zolpidem extended-release in the long-term treatment of insomnia
358doi:10.1038/ncpneuro0821 | Full Text | PDF (128K)
Epilepsies in children—the power of making a syndrome diagnosis
360doi:10.1038/ncpneuro0826 | Full Text | PDF (124K)
Validation of diagnostic criteria for frontotemporal dementia
362doi:10.1038/ncpneuro0827 | Full Text | PDF (124K)
Viewpoint
Can fMRI replace the Wada test in predicting postsurgical deterioration of verbal memory?
364The future of the Wada test as a predictor of verbal memory function following epilepsy surgery has been debated for some time. Memory mapping based on functional MRI is emerging as a potential alternative. Here, Andres Kanner examines where functional MRI currently stands in this setting.
doi:10.1038/ncpneuro0825 | Full Text | PDF (121K)
Reviews
Diagnosis and treatment of bulbar symptoms in amyotrophic lateral sclerosis
366Bulbar symptoms such as impaired swallowing and speech impairment are frequent features of amyotrophic lateral sclerosis and can markedly reduce life expectancy and quality of life. In this article, Kühnlein et al. highlight the importance of early detection, as well as appropriate treatment and management, of bulbar symptoms in patients with amyotrophic lateral sclerosis, emphasizing the benefits of a multidisciplinary approach.
doi:10.1038/ncpneuro0853 | Full Text | PDF (230K)
Management of acute central retinal artery occlusion
376Central retinal artery occlusion (CRAO) is an acute stroke of the eye that can result in profound visual impairment. Standard noninvasive therapies do not markedly alter the natural history of CRAO, and this has prompted investigations into new treatment strategies. As Chen and Lee discuss in this Review, thrombolytic therapy—especially local intra-arterial fibrinolysis—is showing considerable promise for the acute management of acute CRAO.
doi:10.1038/ncpneuro0811 | Full Text | PDF (297K)
The role of regulatory T cells in multiple sclerosis
384Regulatory T (TREG) cells are emerging as key players in the pathogenetic scenario of CNS autoimmune inflammation. In this article, Zozulya and Wiendl discuss how TREG-cell dysfunction might influence the disease course in multiple sclerosis and experimental autoimmune encephalomyelitis, highlighting the importance of interactions between TREG cells and dendritic cells. The authors also assess the potential for therapeutic use of these cell types in patients with multiple sclerosis.
doi:10.1038/ncpneuro0832 | Full Text | PDF (460K)
Case Study
A case of enteroviral meningoencephalitis presenting as rapidly progressive dementia
399This Case Study describes a 70-year-old immunocompetent male with rapidly-progressing dementia. Creutzfeldt–Jakob disease was suspected, but a diagnosis of enterovirus encephalitis was confirmed by brain biopsy. The authors discuss the diagnostic challenges presented by this case, and briefly review enteroviral infections of the brain.
doi:10.1038/ncpneuro0804 | Full Text | PDF (278K)
Corrigendum
Article Responses
Reply to Drug Insight: antioxidant therapy in inherited ataxias
E1doi:10.1038/ncpneuro0833 | Full Text
Author response to "Reply to Drug Insight: antioxidant therapy in inherited ataxias"
E2doi:10.1038/ncpneuro0834 | Full Text
Reply to "Epilepsies in children—the power of making a syndrome diagnosis"
E3doi:10.1038/ncpneuro0831 | Full Text
