Increased efficacy of convection-enhanced drug delivery in an animal model
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Convection-enhanced drug delivery (CED) enables the administration of high drug concentrations directly to the brain tissue; however, variability in the extent of convection within the brain might affect the distribution of molecules delivered this way. Building on their previous investigations, Perlstein et al. used MRI to visualize the distribution of maghemite nanoparticles (MNPs)—which might have applications in targeted and slow-release drug delivery—in the brains of Sprague–Dawley rats in order to determine the optimum CED protocol.
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