Study finds no link between hyperinsulinemia and AD-related brain lesions

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Whether the risk of Alzheimer's disease (AD) is increased in patients with diabetes mellitus is a matter of some debate. One hypothesis supporting such a relationship is that, because insulin-degrading enzyme degrades not only insulin but also -amyloid, the greater competition for this enzyme in patients with hyperinsulinemia might result in higher -amyloid loads. However, findings from a recent, retrospective postmortem study have challenged this claim.

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