Amyloid-
-related angiitis: a rare cause of recurrent transient neurological symptoms
Amy Amick*, Jeff Joseph, Nicholas Silvestri and Magdy Selim
Correspondence *Beth Israel Deaconess Medical Center, Department of Neurology, 330 Brookline Avenue, East Campus TCC 810, Boston, MA 02215, USA
Email aamick@bidmc.harvard.edu
This article describes the case of a female patient who presented with transient right-sided weakness, and went on to develop further transient neurological signs and symptoms. A diagnosis of amyloid-
-related angiitis was made at autopsy following a sudden, fatal intracerebral hemorrhage. The authors highlight the importance of considering this diagnosis in patients with difficult-to-localize transient neurological symptoms.
Background A 79-year-old woman presented with transient right-sided weakness. She subsequently developed further transient neurological signs and symptoms across a range of vascular territories. Diagnostic workup revealed no clear etiology. The patient developed a sudden, fatal intracerebral hemorrhage, and the diagnosis was only revealed at autopsy.
Investigations Neurological examination, head CT, brain MRI, fluid-attenuated inversion recovery imaging, magnetic resonance angiography, lumbar puncture, CT angiography, electroencephalography, and brain autopsy.
Diagnosis Amyloid--related angiitis.
Management The patient expired before treatment could be initiated. Immunosuppressants are recommended for future cases.
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