How SAFE is albumin for fluid resuscitation in critically ill patients with traumatic brain injury?
Peter J Kirkpatrick*, Ming-Yuan Tseng and Peter JA Hutchinson
Correspondence *Box 167, Department of Neurosurgery, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK
Email pjk21@medschl.cam.ac.uk
This article has no abstract so we have provided the first paragraph of the full text.
The SAFE-TBI study represents a detailed post-hoc analysis of patients randomized within the original SAFE investigation who had suffered from primary TBI. A sizable cohort (n = 460) fulfilled accepted criteria for a severe TBI, and a high level of clinical follow-up at 24 months (90% of patients) was achieved. Although many key prognostic variables for severe TBI were reviewed retrospectively, the two groups seem balanced in terms of baseline characteristics. The 24-month death rate was significantly reduced in the saline group (20.4% vs 33.2%; RR 1.63), and the end point of favorable outcome at 24 months also significantly improved in favor of saline (47.3% vs 60.6%; RR 0.78).
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