Diagnostic nerve biopsy: a case history
John W Griffin
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Diagnostic nerve biopsy provides an instructive case history of the developmental arc of a laboratory test. Biopsy of peripheral nerves became a clinically applicable procedure around 40 years ago, and the techniques were developed in the laboratories of pioneers such as Peter Dyck, PK Thomas and Arthur Asbury. In the 20 years that followed, nerve biopsies taught us much about the histopathological basis of nerve disease, and the latest findings were presented at well-attended sessions at annual neurology meetings. We learned the pathology of the inflammatory demyelinating neuropathies, the nature of demyelination and onion-bulb formation in Charcot–Marie–Tooth disease type 1 (CMT1), the features of various types of vasculitic neuropathy, the range of pathology in diabetic nerve injury, and the pathology of various less-prevalent disorders.
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