Review

Nature Clinical Practice Neurology (2008) 4, 216-225
doi:10.1038/ncpneuro0752  
Received 7 August 2007 | Accepted 7 December 2007 | Published online: 26 February 2008

Mechanisms of Disease: pathophysiological concepts of stroke in hemodynamic risk zones—do hypoperfusion and embolism interact?

Alex Förster, Kristina Szabo and Michael G Hennerici*

Correspondence *Department of Neurology, Universitätsklinikum Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1–3, 68167 Mannheim, Germany

Email m.hennerici@neuro.ma.uni-heidelberg.de

Over the past century, the pathophysiology of ischemia in the borderzones between the large cerebral arteries has been the topic of considerable debate. Two seemingly mutually exclusive mechanisms—hemodynamic failure and microembolism—have been proposed to explain this phenomenon. As Förster et al. discuss in this article, a new model of borderzone infarction, incorporating both hypoperfusion and microembolism, is now emerging.

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