Review

Nature Clinical Practice Neurology (2008) 4, 547-556
doi:10.1038/ncpneuro0917  
Received 1 May 2008 | Accepted 20 August 2008 | Published online: 23 September 2008

Neurological manifestations of Waldenström macroglobulinemia

Joachim M Baehring, Ephraim P Hochberg, Noopur Raje, Matthew Ulrickson and Fred H Hochberg*

Correspondence *Pappas Center for Neuro-Oncology, Massachusetts General Hospital, 55 Fruit Street, Yawkey 9010, Boston, MA 02114, USA

Email
 fhochberg@partners.org

Waldenstrom's macroglobulinemia—a condition that is characterized by overproduction of IgM antibodies and most commonly occurs in lymphoplasmacytic lymphoma—is often accompanied by nervous system complications, such as peripheral neuropathy or complications related to serum hyperviscosity. This Review provides an overview of the diagnosis and treatment of such neurological manifestations.

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