Table of contents
September 2007 Volume 3 No 9
Editorial
Viewpoint
Restless legs syndrome: overdiagnosed or underdiagnosed?
474Restless legs syndrome has become increasingly prominent in the clinical literature in recent years, but the prevalence of this condition is still unknown. In this Viewpoint, Claudia Trenkwalder highlights the debate regarding whether restless legs syndrome is overdiagnosed or underdiagnosed, and she considers possible explanations for the differences in opinion within the neurology field.
doi:10.1038/ncpneuro0552 | Full Text | PDF (103K)
Research Highlights
Reduced vital capacity in ALS might be a cause of cognitive dysfunction
476Can inhaled nitrous oxide prevent cerebral palsy in hypertensive newborns?
476PD confers an increased risk of essential tremor in relatives
476doi:10.1038/ncpneuro0566 | Full Text | PDF (101K)
Folic acid supplementation: effective for primary prevention of stroke
477Peripheral-leukocyte profiles could be pharmacologic biomarkers for AD
477doi:10.1038/ncpneuro0568 | Full Text | PDF (101K)
Alternating electric fields disrupt glioblastoma tumor growth in pilot study
478Exposure to haloperidol after methamphetamine causes excitotoxicity
478Human herpesvirus-6B implicated in the etiology of mesial temporal lobe epilepsy
478doi:10.1038/ncpneuro0571 | Full Text | PDF (103K)
Lithium could be a new treatment for spinocerebellar ataxia
479Sustained IL-1
overexpression reduces amyloid pathology in a mouse model of AD
479doi:10.1038/ncpneuro0573 | Full Text | PDF (103K)
Resistance exercise slows functional decline in amyotrophic lateral sclerosis
480Baseline brain function predicts response to restorative therapy for stroke
480doi:10.1038/ncpneuro0575 | Full Text | PDF (101K)
Break recommended every 30 min during transcranial Doppler sonography
481Practice Points
Bilateral pallidal neurostimulation—long-term motor and cognitive effects in primary generalized dystonia
482doi:10.1038/ncpneuro0555 | Full Text | PDF (109K)
Are the first-line recommendations for antiepileptic drug therapy still valid?
484doi:10.1038/ncpneuro0557 | Full Text | PDF (110K)
Can add-on pioglitazone prevent recurrent stroke in patients with type 2 diabetes?
486doi:10.1038/ncpneuro0562 | Full Text | PDF (109K)
Serological diagnosis and follow-up of severe neurocysticercosis using HP10 antigen detection
488doi:10.1038/ncpneuro0563 | Full Text | PDF (109K)
Can functional MRI detect awareness when a neurological examination does not?
490doi:10.1038/ncpneuro0579 | Full Text | PDF (104K)
The evolving role of radiosurgery for metastatic spine tumors
492doi:10.1038/ncpneuro0580 | Full Text | PDF (109K)
Thrombolytic therapy for ischemic stroke—suitable for children?
494doi:10.1038/ncpneuro0581 | Full Text | PDF (107K)
Reviews
Drug Insight: effects mediated by peroxisome proliferator-activated receptor-
in CNS disorders
496Activation of the ligand-inducible transcription factor peroxisome proliferator-activated receptor-
(PPAR) has been shown to suppress inflammation in peripheral macrophages and in models of human autoimmune disease. As Heneka et al. discuss in this Review, PPAR is now being investigated as a potential therapeutic target in CNS disorders with an inflammatory component, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis.
doi:10.1038/ncpneuro0586 | Full Text | PDF (208K)
Diagnosis and management of nonconvulsive status epilepticus in children
505In children, nonconvulsive status epilepticus (NCSE) is associated with various conditions, including acute neurological injuries and specific childhood epilepsy syndromes, and it can also be observed in individuals with learning difficulties. In this article, Korff and Nordli review various aspects of NCSE, including clinical and electroencephalographic features, prognosis, and treatment recommendations. They also highlight the need for further research into NCSE in pediatric populations.
doi:10.1038/ncpneuro0605 | Full Text | PDF (821K)
The Huntington's disease-like syndromes: what to consider in patients with a negative Huntington's disease gene test
517Huntington's disease (HD) accounts for around 90% of cases of chorea of genetic etiology, but a number of other distinct genetic disorders can present with a clinical picture indistinguishable from HD. In this article, Schneider et al. review the clinical features and genetic bases of these HD-like syndromes, discussing the clinical clues that should prompt further investigations in patients presenting with these conditions.
doi:10.1038/ncpneuro0606 | Full Text | PDF (217K)
Case Study
A case of levodopa-responsive camptocormia associated with advanced Parkinson's disease
526doi:10.1038/ncpneuro0584 | Full Text | PDF (199K)
Article Response
Concentric demyelination by self-organization: a new hypothesis for Baló's sclerosis
E1doi:10.1038/ncpneuro0619 | Full Text
