Table of contents
August 2007 Volume 3 No 8
Editorial
Viewpoint
Neurovascular compression syndromes and hypertension: clinical relevance
416The rostral ventrolateral medulla has a major role in the regulation of sympathetic and cardiovascular activities. It has been suggested that neurovascular compression of this area might be causally linked to essential hypertension. In this Viewpoint, the authors highlight the pertinent issues and the clinical relevance of this important debate.
doi:10.1038/ncpneuro0558 | Full Text | PDF (133K)
Research Highlights
Initial studies show new laser treatment to be safe and effective in ischemic stroke
418Fulfilling the potential of convection-enhanced delivery via patient-specific simulation
418Recanalization within 24 h of intravenous thrombolysis improves outcome in stroke
418doi:10.1038/ncpneuro0538 | Full Text | PDF (102K)
Does stress during childhood damage the hippocampus?
419Yoga therapy can ameliorate migraine without aura
419doi:10.1038/ncpneuro0540 | Full Text | PDF (100K)
Neocortical neuritic plaques or neurofibrillary tangles alone do not signify AD
420New method facilitates the targeted delivery of therapeutic proteins to the brain
420Reduced melatonin synthesis is a risk factor for autism spectrum disorders
421Loss of hypocretin neurons might cause sleep disturbance in PD
421SOD1 ALS is biochemically distinct from other familial and sporadic disease forms
421doi:10.1038/ncpneuro0545 | Full Text | PDF (102K)
Compulsory physician reporting of epilepsy might not reduce risk of motor vehicle accident
422TREM-2 promotes neural repair in animal model of multiple sclerosis
422doi:10.1038/ncpneuro0547 | Full Text | PDF (102K)
Increased antithrombotic use puts the over 75s at risk for stroke
423Practice Points
Does lamotrigine alleviate the pain in diabetic neuropathy?
424doi:10.1038/ncpneuro0533 | Full Text | PDF (135K)
Dopamine agonists and the risk of valvular heart disease
426doi:10.1038/ncpneuro0534 | Full Text | PDF (137K)
Should MRI replace CT for the routine evaluation of acute stroke?
428doi:10.1038/ncpneuro0532 | Full Text | PDF (135K)
Predictors of respiratory failure in Guillain–Barré syndrome
430doi:10.1038/ncpneuro0535 | Full Text | PDF (137K)
Quick screen for cognitive impairment in patients with multiple sclerosis
432doi:10.1038/ncpneuro0554 | Full Text | PDF (135K)
Reviews
HIV-associated cognitive impairment in sub-Saharan Africa—the potential effect of clade diversity
436In this Review, Sacktor et al. summarize our current understanding of HIV-associated cognitive impairment in resource-limited settings, focusing specifically on the countries of sub-Saharan Africa. They also consider the potential impact of HIV-1 clade diversity on HIV-associated neurological disease.
doi:10.1038/ncpneuro0559 | Full Text | PDF (1,352K)
Technology Insight: future neuroprosthetic therapies for disorders of the nervous system
444The emerging field of neuroprosthetics is focused on the development of therapeutic interventions that restore lost neural function by stimulating sensory or motor pathways, or by harnessing activity recorded from remnant neural pathways to control an external device. As Richard Normann discusses in this Review, penetrating microelectrode arrays are providing unprecedented selective access to the neurons of the CNS and PNS, and are likely to form the basis for new therapies for disorders of the nervous system.
doi:10.1038/ncpneuro0556 | Full Text | PDF (628K)
Mechanisms of Disease: inherited demyelinating neuropathies—from basic to clinical research
453Charcot–Marie–Tooth disease is the most common inherited disease of the PNS. This Review summarizes our current understanding of the genetic and molecular mechanisms that underlie the demyelinating forms of Charcot–Marie–Tooth disease. The authors also discuss how knowledge of these mechanisms is guiding the development of strategies to diagnose and treat these conditions in the clinic.
doi:10.1038/ncpneuro0583 | Full Text | PDF (384K)
Case Study
A case of acute ischemic stroke: optimizing management with penumbra and vessel imaging
465doi:10.1038/ncpneuro0553 | Full Text | PDF (267K)
Training Matters
Virtual reality training for carotid intervention
470Virtual reality simulation has a growing role in teaching physicians to perform high-risk, complex or technically demanding procedures. In this Training Matters article, David Dawson discusses the benefits of using this approach for training in carotid artery stenting.
doi:10.1038/ncpneuro0578 | Full Text | PDF (133K)
