Microglial activation is a marker of presymptomatic HD
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Researchers have demonstrated that there is early and widespread activation of microglia in Huntington's disease (HD) presymptomatic gene carriers (PGCs), and have shown a strong relationship between this process and striatal neuronal dysfunction. They have also established the utility of the PET tracer 11C-(R)-PK11195 (PK) as a marker of subclinical disease progression in HD. PK binds selectively to the peripheral benzodiazepine binding sites expressed by microglia when these cells are activated by neuronal insult.
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