Extended hypoestrogenicity negates the neuroprotective effect of estrogen therapy
This article has no abstract so we have provided the first paragraph of the full text.
Ischemic injury is known to trigger an inflammatory response that contributes to brain injury. Many observational and retrospective studies in postmenopausal women have shown a neuroprotective effect of estrogen therapy (ET). Evidence indicates that this neuroprotective action might be attributable to estrogen's anti-inflammatory actions; however, neither the Women Estrogen Stroke Trial (WEST) nor the Women's Health Initiative (WHI) found any neuroprotective benefits associated with ET. Now, research conducted by Suzuki et al. has provided a potential explanation for the negative findings of these trials.
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