Table of contents
June 2007 Volume 3 No 6
Editorial
Viewpoint
Collaboration to promote neurological research—the European Brain Council experience
298A recent study has shown that brain research is poorly funded compared with research in fields such as cancer and heart disease. In this Viewpoint, Jes Olesen discusses possible reasons for this discrepancy, and describes how the European Brain Council is bringing together basic neuroscientists, clinical neurologists and patient organizations to promote brain research and to facilitate the translation of new advances into real benefits for patients.
Research Highlights
Benefits of mental practice in rehabilitation of patients with stroke
300Can MRI and CSF neurofilament profiles differentiate AD and frontotemporal dementia?
300Spatial navigation impairment: a potential biomarker of AD
301Using preoperative fiber tracking to preserve pyramidal tracts during brain tumor removal
301RLS: a potentially treatable manifestation of diabetic neuropathy
302Fever following subarachnoid hemorrhage is associated with poor outcome
302The symptoms of Rett syndrome could be reversible
302No link between mobile phone use and increased risk of glioma
303Study finds no evidence to support restriction of seafood consumption during pregnancy
303'Virtual walking' alleviates phantom pain after spinal cord injury
304Evidence of anatomical changes in the brains of patients with migraine
304A simple score can predict 2-day stroke risk after transient ischemic attack
305Practice Points
Does adjunctive lamotrigine provide improved control of primary generalized tonic–clonic seizures in children?
306Clinical correlates of Lewy-body-related disorders: splitting and lumping or lumping and splitting?
308Sentinel headaches in patients with subarachnoid hemorrhage: implications for patient management
310First seizure presentation with multiple discrete seizures within 24 hours: implications for diagnosis and treatment
312Cerebral palsy—are the definitions of the Gross Motor Functional Classification System too broad?
314Lumbar disc herniation—to operate or not to operate?
316Reviews
Etiology and management of refractory epilepsies
320Around a third of patients with epilepsy have refractory epilepsy; that is, they continue to have seizures despite trying a range of antiepileptic drugs. Recent basic research has explored the underlying causes of refractory epilepsy, and in this article Sanjay Sisodiya discusses the two main hypotheses that have emerged from these studies. He also considers how knowledge of the molecular basis of refractoriness might guide the development of new therapies.
doi:10.1038/ncpneuro0521 | Full Text | PDF (260K)
Diabetic neuropathy—a review
331Diabetic neuropathy—the most common neuropathy in industrialized countries—encompasses a broad range of clinical manifestations. In this Review, Gérard Said discusses the clinical, pathological and therapeutic aspects of various forms of diabetic neuropathy, including length-dependent diabetic polyneuropathy and focal diabetic neuropathies. The author also addresses the diagnosis of nondiabetic neuropathies in patients with diabetes.
doi:10.1038/ncpneuro0504 | Full Text | PDF (610K)
Technology Insight: can neuroimaging provide insights into the role of ischemia in Baló's concentric sclerosis?
341Baló's concentric sclerosis (BCS) is a demyelinating disorder characterized by white matter lesions consisting of rings of demyelination alternating with rings of relatively intact myelin. In this Review, Mowry et al. discuss how advanced neuroimaging techniques have contributed to our understanding of the pathogenesis of BCS, as well as enabling clinicians to distinguish BCS from other demyelinating disorders such as multiple sclerosis. The authors explore these themes further in a Case Study in this issue.
doi:10.1038/ncpneuro0519 | Full Text | PDF (240K)
Case Study
Baló's concentric sclerosis presenting as a stroke-like syndrome
349doi:10.1038/ncpneuro0522 | Full Text | PDF (289K)
Article Response
Neurotoxicity of levodopa: treatment-associated homocysteine increase
E1doi:10.1038/ncpneuro0527 | Full Text
