Table of contents
February 2007 Volume 3 No 2
Editorial
Viewpoints
The current status of mild cognitive impairment—what do we tell our patients?
60Ronald Petersen developed the concept of mild cognitive impairment (MCI) in the late 1990s. The concept has since been expanded to include several subtypes, with amnestic MCI being recognized as a risk state for Alzheimer's disease. This Viewpoint highlights the benefits of retaining the MCI classification, both from a research and from a clinical point of view.
Mild cognitive impairment—a confused concept?
62Mild cognitive impairment has become a popular concept for classifying the boundaries between normal aging and dementia, but is it a legitimate diagnosis? In this Viewpoint article, Peter Whitehouse argues that the concept of mild cognitive impairment is fundamentally flawed and driven to a large extent by stakeholder interests.
Research Highlights
Preliminary report on corticosteroid therapy for ataxia-telangiectasia
64Electronic neural implant aids functional reorganization of the motor cortex
64Self-regulation of slow negative brain potentials can improve symptoms of ADHD
64Inhibition of the Alzheimer's 
-secretase with modified heparan sulfate analogs
65No evidence of a neuroprotective effect for TCH346 in Parkinson's disease
66Patients with imploding migraine headache respond to botulinum A toxin therapy
66New evidence of serotonergic dysfunction in sudden infant death syndrome
67Characterization of the human inflammatory response to spinal cord injury
67Spreading depolarizations are indicators of brain damage after subarachnoid hemorrhage
67Arginine growth hormone stimulation test can distinguish between MSA and PD
68Antiglycolytic compounds: a new class of drugs for treating epilepsy
68Symptoms of undiagnosed stroke are commonplace in the general population
69Practice Points
Does deep brain stimulation of the subthalamic nucleus in Parkinson's disease affect cognition and behavior?
70Acute ischemic stroke—are hemodynamic variables predictive of outcome after systemic thrombolysis?
72Migraine and cardiovascular disease: is there a link?
74Magnetic resonance spectroscopic imaging—of prognostic value in amyotrophic lateral sclerosis?
76Cerebellar tumors in pediatric patients: can they be differentiated using diffusion-weighted imaging?
78Reviews
Herpesvirus infections of the nervous system
82Most human herpesviruses are neurotropic and have the capability to cause serious acute and chronic neurological diseases of the nervous system. In this article, Gilden et al. review current knowledge regarding the clinical features, pathogenesis and treatment of the various neurological complications that can result from herpesvirus infections.
doi:10.1038/ncpneuro0401 | Full Text | PDF (361K)
Neurological manifestations in Fabry's disease
95Fabry's disease is an X-linked lysosomal storage disorder, the primary pathology of which is accumulation of glycosphingolipids in cells throughout the body, including the nervous system. Neurological symptoms, which include pain, abnormal sensations and stroke, are evident early in the disease course. In this Review, Møller and Jensen highlight the importance of recognizing these symptoms in order to ensure a rapid diagnosis.
doi:10.1038/ncpneuro0407 | Full Text | PDF (537K)
Case Study
Fragile X-associated tremor/ataxia syndrome—an older face of the fragile X gene
107doi:10.1038/ncpneuro0373 | Full Text | PDF (338K)
