Table of contents
November 2007 Volume 3 No 11
Viewpoint
Publication bias against negative results from clinical trials: three of the seven deadly sins
590There is strong evidence that clinical trials with a positive outcome are more likely to be published than are trials with negative results. In this Viewpoint, Richard Johnson and Kay Dickersin explore the reasons for this phenomenon and discuss possible solutions.
doi:10.1038/ncpneuro0618 | Full Text | PDF (117K)
Research Highlights
A technique for in vitro amplification of PrPSc and detection of vCJD infectivity
592doi:10.1038/ncpneuro0588 | Full Text | PDF (124K)
Lacunar lesion burden predicts cognitive impairment and disability in CADASIL
592Human neural stem cells improve function in primate model of severe Parkinson's disease
593Newly designed drugs mimic effect of mood stabilizers
593doi:10.1038/ncpneuro0600 | Full Text | PDF (124K)
Mandatory folic-acid fortification reduces prevalence of neural-tube defects in Canada
594Statins reduce the incidence of dementia and Parkinson's disease to varying extents
594Study raises questions about use of sodium-channel blockers in neuroinflammatory disorders
595Rat studies point to a novel treatment strategy for ALS
595Deep brain stimulation promotes late functional recovery after traumatic brain injury
595doi:10.1038/ncpneuro0624 | Full Text | PDF (124K)
Quetiapine targets oligodendrocytes and could be a treatment for schizophrenia
596Intramuscular anti-
-amyloid immunotherapy for AD
596doi:10.1038/ncpneuro0626 | Full Text | PDF (124K)
Polymorphism in 5-HT transporter gene is associated with tolerance of rotating shift work
597doi:10.1038/ncpneuro0627 | Full Text | PDF (100K)
Practice Points
Improved prediction of outcomes in patients with acute intracranial hemorrhage
598doi:10.1038/ncpneuro0633 | Full Text | PDF (123K)
Clinical assessment of progressive supranuclear palsy over time: new rating scale validated
600doi:10.1038/ncpneuro0603 | Full Text | PDF (121K)
Dopamine transporter brain imaging—can it improve the differential diagnosis of dementia with Lewy bodies?
602doi:10.1038/ncpneuro0585 | Full Text | PDF (126K)
Sumatriptan–naproxen combination for acute migraine
604doi:10.1038/ncpneuro0615 | Full Text | PDF (121K)
Flu-related neurological complications: incidence and risk factors in children
606doi:10.1038/ncpneuro0610 | Full Text | PDF (122K)
Can diffusion-weighted imaging improve the diagnosis of CNS vasculitis?
608doi:10.1038/ncpneuro0614 | Full Text | PDF (121K)
Reviews
Emerging therapies for migraine
610Migraine is a common disabling brain disorder that—considering its clinical and economic impact—is understudied and in need of additional management options. In this Review, Peter Goadsby outlines new pharmaceutical and device-based approaches to migraine treatment by describing their potential mechanisms of action and the clinical data that are currently available.
doi:10.1038/ncpneuro0639 | Full Text | PDF (219K)
The effect of white matter lesions on cognition in the elderly—small but detectable
620The extent to which white matter lesions affect brain function in elderly individuals has important implications for the development of drugs to treat cognitive impairment and dementia. In this article, Frisoni et al. argue that white matter lesions can contribute to cognitive impairment in elderly individuals, although their effects are minor when compared with those of other causes of cognitive deterioration, such as Alzheimer's disease.
doi:10.1038/ncpneuro0638 | Full Text | PDF (443K)
Surgery Insight: the role of surgery in the management of low-grade gliomas
628Surgery is becoming a viable treatment option for an increasing proportion of patients with low-grade gliomas, but there is a lack of class I evidence to support its efficacy. In this Review, Pouratian et al. critically analyze the utility of surgery in low-grade glioma. They highlight recent technological advances that have made this approach safer and more accessible, and consider the challenges involved in designing trials to assess the extent to which aggressive resection improves prognosis.
doi:10.1038/ncpneuro0634 | Full Text | PDF (438K)
Case Study
Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11
640In this Case Study, the authors describe how sulfonylurea therapy not only restored glucose homeostasis, but also alleviated some of the neurological symptoms in a patient with intermediate DEND syndrome. Single-photon emission CT provided evidence of increased CNS blood flow and function that correlated with mental and motor improvements.
doi:10.1038/ncpneuro0640 | Full Text | PDF (467K)
