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From the following article:

Sulfonylurea improves CNS function in a case of intermediate DEND syndrome caused by a mutation in KCNJ11

Wojciech Mlynarski, Andrei I Tarasov, Agnieszka Gach, Christophe A Girard, Iwona Pietrzak, Lejla Zubcevic, Jacek Kusmierek, Tomasz Klupa, Maciej T Malecki and Frances M Ashcroft

Nature Clinical Practice Neurology (2007) 3, 640-645
doi:10.1038/ncpneuro0640

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Single-photon emission CT imaging of a patient with neonatal diabetes caused by a missense mutation (His46Leu) in KCNJ11 indicates an improvement in brain blood flow following glibenclamide therapy.

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Figure 2 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 2

Functional analysis of KATP channels carrying the Kir6.2-His46Leu mutation demonstrates reduced ATP sensitivity but robust block by sulfonylureas.

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