You can't cure a disease by throwing money at it, can you?

John W Griffin

doi:10.1038/ncpneuro0629 | Full Text | PDF (94K)

Should cranial MRI screening of preterm infants become routine?

Linda S de Vries and Frances M Cowan

Recent data show that MRI at term-equivalent age can predict neurodevelopmental outcomes in infants born far before term. So should cranial MRI screening replace cranial ultrasound in preterm babies? The authors of this Viewpoint weigh up the options.

doi:10.1038/ncpneuro0608 | Full Text | PDF (133K)

Mast cell stabilization might improve outcomes after tPA thrombolysis in ischemic stroke

doi:10.1038/ncpneuro0587 | Full Text | PDF (91K)

Variations in regulatory regions of APOE affect the rate of cognitive decline in AD

doi:10.1038/ncpneuro0589 | Full Text | PDF (91K)

Short pulse widths effective in deep brain stimulation for primary generalized dystonia

doi:10.1038/ncpneuro0590 | Full Text | PDF (101K)

Study demonstrates the safety and tolerability of in vivo gene therapy in the human brain

doi:10.1038/ncpneuro0591 | Full Text | PDF (91K)

Relationship between topiramate and language disturbance in migraine

doi:10.1038/ncpneuro0592 | Full Text | PDF (100K)

Primary somatosensory cortical involvement in idiopathic RLS

doi:10.1038/ncpneuro0594 | Full Text | PDF (84K)

Virus-derived peptide enables transvascular delivery of small interfering RNA to the CNS

doi:10.1038/ncpneuro0596 | Full Text | PDF (98K)

Inflammatory MS lesions linked to characteristic metabolic profile in cerebrospinal fluid

doi:10.1038/ncpneuro0598 | Full Text | PDF (88K)

Glioblastoma multiforme proximity to neural stem cells predicts malignancy

doi:10.1038/ncpneuro0599 | Full Text | PDF (88K)

Changes in plasma levetiracetam concentrations in pregnant women and their breastfed infants

Emilio Perucca

doi:10.1038/ncpneuro0604 | Full Text | PDF (140K)

Investigating glatiramer acetate for relapsing–remitting multiple sclerosis at the double dose—is more better?

Peter A Calabresi

doi:10.1038/ncpneuro0612 | Full Text | PDF (139K)

Prevention of venous thromboembolism in patients with stroke—enoxaparin vs unfractionated heparin

Richard A Bernstein

doi:10.1038/ncpneuro0613 | Full Text | PDF (137K)

Diffusion tensor MRI for the differentiation of Parkinson's disease and multiple system atrophy

Olga Ciccarelli

doi:10.1038/ncpneuro0609 | Full Text | PDF (133K)

Injury and recovery in the developing brain: evidence from functional MRI studies of prematurely born children

Laura R Ment and R Todd Constable

Prematurely born infants are at high risk of brain injury, but although structural and volumetric alterations often persist into later life, there is strong evidence of recovery from cognitive impairments associated with preterm birth. In this Review, Ment and Constable discuss how functional MRI techniques are providing important insights into the adaptive mechanisms of the developing preterm brain, including the engagement of alternative neural networks for language and memory.

doi:10.1038/ncpneuro0616 | Full Text | PDF (629K)

Mechanisms of Disease: basic-research-driven investigations in humans—the case of hyperkinetic disorders

Diego Centonze, Giorgio Bernardi and Giacomo Koch

Findings in animal models of Huntington's disease and levodopa-induced dyskinesia indicate that corticostriatal long-term potentiation is abnormally stable in these conditions, causing persistent inhibition of the output nuclei of the basal ganglia, which leads to involuntary movements. In this article, Centonze et al. review evidence that repetitive transcranial magnetic stimulation can interfere with the maintenance of corticostriatal long-term potentiation in humans, and might, therefore, be useful as an antidyskinetic treatment.

doi:10.1038/ncpneuro0617 | Full Text | PDF (369K)

Neurology residency training in the US and Poland

Ralph F Józefowicz

Neurology residency education is undergoing considerable change in many countries, not least the US and Poland. Ralph F Józefowicz, who has experience with neurology residency training in both countries, compares their respective training programs and argues that the two systems have much to learn from one another during the reform process.

doi:10.1038/ncpneuro0611 | Full Text | PDF (132K)