Child neurology: a separate and necessary discipline

Donna M Ferriero and Stephen Ashwal

doi:10.1038/ncpneuro0343 | Full Text | PDF (57K)

Strategies for therapy in acute ischemic stroke

Alastair M Buchan and James Kennedy

In this Viewpoint article, Alastair Buchan and James Kennedy evaluate emerging options for the treatment of acute ischemic stroke and discuss the difficulties associated with choosing the patients who might benefit most from them.

doi:10.1038/ncpneuro0393 | Full Text | PDF (85K)

Statins improve endothelial function in patients with lacunar infarctions

doi:10.1038/ncpneuro0327 | Full Text | PDF (67K)

New evidence-based guidelines for the management of transient ischemic attack

doi:10.1038/ncpneuro0328 | Full Text | PDF (67K)

Increased cortical excitability could induce epileptic seizures after sleep deprivation

doi:10.1038/ncpneuro0361 | Full Text | PDF (83K)

Abnormal gait function could be used to screen for autism

doi:10.1038/ncpneuro0362 | Full Text | PDF (65K)

Thiorphan has neuroprotective effects

doi:10.1038/ncpneuro0363 | Full Text | PDF (82K)

Treatment-resistant depression responds to repetitive transcranial magnetic stimulation

doi:10.1038/ncpneuro0364 | Full Text | PDF (66K)

A mutant lysosomal ATPase causes hereditary parkinsonism

doi:10.1038/ncpneuro0365 | Full Text | PDF (66K)

Herpes simplex virus-1 associates with changes in brain morphology in schizophrenia

doi:10.1038/ncpneuro0366 | Full Text | PDF (84K)

High-dose EPO improves cognitive function in chronic schizophrenia

doi:10.1038/ncpneuro0367 | Full Text | PDF (65K)

Ubiquitinated TDP-43 is associated with FTLD and ALS

doi:10.1038/ncpneuro0368 | Full Text | PDF (83K)

Fingolimod shows therapeutic potential for relapsing multiple sclerosis

doi:10.1038/ncpneuro0369 | Full Text | PDF (65K)

Sleep-related breathing disorder increases the risk of developing depression

doi:10.1038/ncpneuro0370 | Full Text | PDF (83K)

Delayed carotid endarterectomy recommended for patients with completed stroke

doi:10.1038/ncpcardio0696 | Full Text | PDF (67K)

Increased urine aluminum levels found in patients with MS

doi:10.1038/ncpneuro0371 | Full Text | PDF (67K)

Headache in the emergency department—how to identify patients at risk of serious underlying pathology

Brian M Grosberg

doi:10.1038/ncpneuro0360 | Full Text | PDF (87K)

Is there a link between aspirin therapy and stroke severity?

Philip M Bath

doi:10.1038/ncpneuro0349 | Full Text | PDF (86K)

Should patients with anaplastic oligodendroglial tumors receive adjuvant chemotherapy?

Mark R Gilbert and Frederick F Lang

doi:10.1038/ncpneuro0375 | Full Text | PDF (89K)

Complex regional pain syndrome—are we neglecting neglect?

Jörn Schattschneider

doi:10.1038/ncpneuro0374 | Full Text | PDF (88K)

Do all patients with Duchenne muscular dystrophy require surgery for the correction of scoliosis?

Jonathan B Strober

doi:10.1038/ncpneuro0359 | Full Text | PDF (87K)

Do poststroke MRI findings predict the type of a subsequent stroke?

Clinton B Wright

doi:10.1038/ncpneuro0377 | Full Text | PDF (86K)

Do patients with neurocysticercosis benefit from cysticidal therapy?

Larry E Davis

doi:10.1038/ncpneuro0378 | Full Text | PDF (90K)

Primary CNS lymphoma

Fred H Hochberg, Joachim M Baehring and Ephraim P Hochberg

Primary CNS lymphoma, an extranodal non-Hodgkin's lymphoma that invades the nervous system, accounts for around 3% of all primary brain tumors. In this Review, Hochberg et al. highlight recent advances in our understanding of the pathogenesis of primary CNS lymphoma, and they discuss current approaches to the diagnosis and therapy of this condition.

doi:10.1038/ncpneuro0395 | Full Text | PDF (661K)

Drug Insight: the use of intravenous immunoglobulin in neurology—therapeutic considerations and practical issues

Ralf Gold, Martin Stangel and Marinos C Dalakas

Intravenous immunoglobulin has an important role in the treatment of numerous neuroimmunological disorders, including Guillain–Barré syndrome and multiple sclerosis. In this article, Gold et al. review current and future indications for intravenous immunoglobulin treatment, discuss its proposed mechanisms of action, and highlight various practical issues relating to its use in the clinic.

doi:10.1038/ncpneuro0376 | Full Text | PDF (228K)

Technology Insight: recanalization with drugs and devices during acute ischemic stroke

Wade S Smith

Revascularization has a pivotal role in ischemic stroke therapy, and strokes involving small blood vessels respond well to intravenously administered thrombolytic drugs. Large-vessel strokes carry higher morbidity and mortality than small-vessel strokes, and are less amenable to thrombolytic approaches. In this Review, Wade Smith assesses recent data indicating that recanalization of large vessels can be achieved using mechanical clot retrieval devices.

doi:10.1038/ncpneuro0372 | Full Text | PDF (334K)