Mechanisms of Disease: what factors limit the success of peripheral nerve regeneration in humans?
Ahmet Höke
Correspondence Johns Hopkins Hospital, Department of Neurology, Pathology 509, 600 N Wolfe Street, Baltimore, MD 21287, USA
Email ahoke@jhmi.edu
Although adult mammalian peripheral axons are able to regenerate after injury, this does not always translate into successful functional recovery after nerve injury in humans. In this review, Ahmet Höke considers the cellular and molecular factors that limit peripheral nerve regeneration in humans, and discusses how new animal models might be developed to investigate these barriers to regeneration and to test novel therapeutic approaches.
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