Research Highlights

Nature Clinical Practice Neurology (2006) 2, 294-295
doi:10.1038/ncpneuro0189  

An amyloid-bold beta protein assembly in the brain is linked with impaired memory

Pippa Murdie

This article has no abstract so we have provided the first paragraph of the full text.

In a letter published in Nature, Lesné and co-workers have described a novel mechanism of memory impairment that could contribute to the cognitive deficits associated with Alzheimer's disease. This mechanism, which involves extracellular accumulation of a 56 kDa soluble amyloid-beta (Abeta) assembly, dubbed Abeta*56, has been shown to induce memory deficit in middle-aged Tg2576 MICE, independently of plaques or neuronal loss.

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