An amyloid-
protein assembly in the brain is linked with impaired memory
Pippa Murdie
This article has no abstract so we have provided the first paragraph of the full text.
In a letter published in Nature, Lesné and co-workers have described a novel mechanism of memory impairment that could contribute to the cognitive deficits associated with Alzheimer's disease. This mechanism, which involves extracellular accumulation of a 56 kDa soluble amyloid-
(A
) assembly, dubbed A
*56, has been shown to induce memory deficit in middle-aged Tg2576 MICE, independently of plaques or neuronal loss.
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