Table of contents
May 2006 Volume 2 No 5
Editorial
Viewpoint
Using molecular information to guide brain tumor therapy
232The ability to classify brain tumors on the basis of molecular data is expected to revolutionize the diagnosis and treatment of brain cancer. In this Viewpoint article, Mischel and Cloughesy discuss the current status of molecularly targeted therapies for brain tumors, and outline a 'roadmap' for future investigations.
Research Highlights
Perinatal infection with neurotropic viruses is associated with cerebral palsy
234Cerebral microhemorrhage implicated in progression of Alzheimer's disease
234Could chronic wasting disease be transmitted by contact with meat from prion-infected deer?
234A website that gives personalized feedback might improve migraine management
235Event-related potentials identify patients with early-stage AD
235Link between newborn encephalopathy and autism spectrum disorders?
236Genetic polymorphism affects timing of levodopa-induced dyskinesias in PD
236Gefitinib treatment for brain metastases in patients with EGFR gene mutations
236Serum GFAP: an early indicator of intracerebral hemorrhage in acute stroke
237Reducing AEDs does not increase relapse risk after surgery for epilepsy
237Inhibition of a downstream effector of COX2 can attenuate excitotoxic brain injury
238Practice Points
Can infant eye closure during paroxysmal events help differentiate nonepileptic activity from seizures?
240Can lumiracoxib safely and effectively treat episodic tension-type headache?
242The Recognition of Stroke in the Emergency Room (ROSIER) scale: a useful diagnostic tool?
244Can visual hallucinations be used as a diagnostic factor in Parkinson's disease?
246Which factors influence the prognosis in patients with spinal ependymomas?
248Reviews
Genetic neurological channelopathies
252It is becoming clear that certain forms of many human neurological disorders, including myotonia, periodic paralysis, epilepsy and migraine, can be attributed to genetically induced ion-channel dysfunction. In this review, Michael Hanna discusses the clinical, genetic and electrophysiological features of a range of neurological channelopathies that are caused by mutations in single genes.
doi:10.1038/ncpneuro0178 | Full Text | PDF (261K)
West Nile virus meningoencephalitis
264Since its first appearance in the US in 1999, the arthropod-borne flavivirus West Nile virus has emerged as the main cause of epidemic meningoencephalitis in North America. DeBiasi and Tyler review the epidemiology, clinical features, diagnosis and prognosis of West Nile virus neuroinvasive disease, and discuss current treatments and prospects for future therapies.
doi:10.1038/ncpneuro0176 | Full Text | PDF (826K)
Therapy Insight: neurological complications of prediabetes
276Stroke and peripheral neuropathy are recognized neurological complications of diabetes, and epidemiological evidence is now emerging to implicate the prediabetic state of impaired glucose tolerance as a risk factor for these conditions. Singleton and Smith assess this evidence, and also consider the possibility of a link between impaired glucose tolerance and cognitive dysfunction.
doi:10.1038/ncpneuro0172 | Full Text | PDF (157K)
Case Study
The role of spinal cord imaging in the diagnosis of multiple sclerosis
283doi:10.1038/ncpneuro0169 | Full Text | PDF (172K)
