Table of contents
February 2006 Volume 2 No 2
Editorial
Viewpoint
'Pandora's box' of incidental findings in brain imaging research
60Procedures for handling incidental findings in brain imaging research vary widely. Through considering the principles that govern how incidental findings should be dealt with, the author highlights concepts and strategies to help guide researchers and practitioners through the choices they must make.
Research Highlights
Functionally different antiepileptic drugs have differing effects on male sexual function
62Early cardiac screening and genetic analysis in patients with muscular dystrophy
62Importance of COMT and PRODH in psychosis development
63Can tryptophan metabolites slow progression of multiple sclerosis?
63Vitamin B2 shows promise as a treatment for traumatic brain injury
64Video-EEG monitoring in patients with atypical juvenile myoclonic epilepsy
65Novel test for baroreceptor dysfunction in Parkinson's disease
65Increased risk of stroke associated with hyperglycemia
66The association of Guillain–Barré syndrome with mental-status abnormalities
67Practice Points
Should MRI signs be included in the diagnostic criteria for sporadic Creutzfeldt–Jakob disease?
68How useful is the HIT-6™ for measuring headache-related disability?
70Can pathological patterns be used to guide individualized multiple sclerosis therapy?
72Are migraine and headache associated with an increased risk of stroke in women?
74
treatment for multiple sclerosis?Reviews
Therapy Insight: the impact of type 1 diabetes on brain development and function
78Even in cases of well-controlled type 1 diabetes, cerebral glucose levels are frequently abnormal, and this is thought to have an impact on brain development and function. This article reviews the emerging literature that documents pathophysiological CNS changes and neurocognitive deficits in adults and children with type 1 diabetes, and discusses the implications for the clinical management of these patients.
doi:10.1038/ncpneuro0097 | Full Text | PDF (185K)
Surgery Insight: current management of epidural spinal cord compression from metastatic spine disease
87Skeletal system metastases are the third most common type of metastases in patients with cancer, and metastatic epidural spinal cord compression (MESCC) is estimated to occur in 5–10% of all cancer patients. In this review, Witham et al. discuss current strategies for the clinical management of MESCC, including radiotherapeutic and surgical approaches, and they also consider some emerging treatment options.
doi:10.1038/ncpneuro0116 | Full Text | PDF (392K)
Mechanisms of Disease: neuropathic pain—a clinical perspective
95Neuropathic pain is caused by damage to the parts of the nervous system that normally signal pain. Attempts to classify neuropathic pain patients on the basis of disease etiology or lesion topography have met with limited success, and in this review Ralf Baron presents an alternative system based on molecular mechanisms. He discusses how this approach might lead to the development of more rational treatments for neuropathic pain.
doi:10.1038/ncpneuro0113 | Full Text | PDF (295K)
Mechanisms of Disease: mechanism-based classification of neuropathic pain—a critical analysis
107In this issue, Ralf Baron has described the molecular mechanisms that underlie neuropathic pain, but how close are we to translating these mechanisms into viable treatment strategies in the clinic? In this accompanying review, Nanna Finnerup and Troels Jensen address this question through a critical evaluation of the mechanism-based approach to neuropathic pain classification.
doi:10.1038/ncpneuro0118 | Full Text | PDF (216K)
