Nature Clinical Practice Neurology Nature Clinical Practice Neurology provides physicians with authoritative and timely interpretations of key developments in the field, translating the latest findings into clinical practice. http://www.nature.com/ncpneuro/current_issue/ Nature Publishing Group en © 2008 Nature Publishing Group Nature Clinical Practice Neurology 1745-834X 1743-4300 © 2008 Nature Publishing Group permissions@nature.com Nature Clinical Practice Neurology http://www.nature.com/includes/rj_globnavimages/ncpneuro_logo.gif http://www.nature.com/ncpneuro/ Redressing the balance in autism research http://dx.doi.org/10.1038/ncpneuro0860 Redressing the balance in autism research

Nature Clinical Practice Neurology 4, 407 (2008). doi:10.1038/ncpneuro0860

Author: Patricia Howlin

]]> Redressing the balance in autism research Patricia Howlin doi:10.1038/ncpneuro0860 Nature Clinical Practice Neurology 4, 407 (2008) Nature Clinical Practice Neurology 4 8 Editorial 407 407 CABG surgery does not increase the risk of late cognitive decline http://dx.doi.org/10.1038/ncpneuro0837 CABG surgery does not increase the risk of late cognitive decline

Nature Clinical Practice Neurology 4, 408 (2008). doi:10.1038/ncpneuro0837

]]> CABG surgery does not increase the risk of late cognitive decline doi:10.1038/ncpneuro0837 Nature Clinical Practice Neurology 4, 408 (2008) Nature Clinical Practice Neurology 4 8 Research Highlights 408 408 Mutations in protocadherin gene lead to female epilepsy and mental retardation http://dx.doi.org/10.1038/ncpneuro0838 Mutations in protocadherin gene lead to female epilepsy and mental retardation

Nature Clinical Practice Neurology 4, 408 (2008). doi:10.1038/ncpneuro0838

]]> Mutations in protocadherin gene lead to female epilepsy and mental retardation doi:10.1038/ncpneuro0838 Nature Clinical Practice Neurology 4, 408 (2008) Nature Clinical Practice Neurology 4 8 Research Highlights 408 408 Repetitive magnetic stimulation shows promise in rehabilitation after pediatric stroke http://dx.doi.org/10.1038/ncpneuro0839 Repetitive magnetic stimulation shows promise in rehabilitation after pediatric stroke

Nature Clinical Practice Neurology 4, 408 (2008). doi:10.1038/ncpneuro0839

]]> Repetitive magnetic stimulation shows promise in rehabilitation after pediatric stroke doi:10.1038/ncpneuro0839 Nature Clinical Practice Neurology 4, 408 (2008) Nature Clinical Practice Neurology 4 8 Research Highlights 408 409 Subcortical hyperintensities predict conversion to dementia http://dx.doi.org/10.1038/ncpneuro0840 Subcortical hyperintensities predict conversion to dementia

Nature Clinical Practice Neurology 4, 409 (2008). doi:10.1038/ncpneuro0840

]]> Subcortical hyperintensities predict conversion to dementia doi:10.1038/ncpneuro0840 Nature Clinical Practice Neurology 4, 409 (2008) Nature Clinical Practice Neurology 4 8 Research Highlights 409 409 Oral cleft malformations in lamotrigine-exposed infants http://dx.doi.org/10.1038/ncpneuro0841 Oral cleft malformations in lamotrigine-exposed infants

Nature Clinical Practice Neurology 4, 409 (2008). doi:10.1038/ncpneuro0841

]]> Oral cleft malformations in lamotrigine-exposed infants doi:10.1038/ncpneuro0841 Nature Clinical Practice Neurology 4, 409 (2008) Nature Clinical Practice Neurology 4 8 Research Highlights 409 410 Risk of stroke elevated by use of rofecoxib or valdecoxib http://dx.doi.org/10.1038/ncpneuro0842 Risk of stroke elevated by use of rofecoxib or valdecoxib

Nature Clinical Practice Neurology 4, 410 (2008). doi:10.1038/ncpneuro0842

]]> Risk of stroke elevated by use of rofecoxib or valdecoxib doi:10.1038/ncpneuro0842 Nature Clinical Practice Neurology 4, 410 (2008) Nature Clinical Practice Neurology 4 8 Research Highlights 410 410 Delayed myelin destruction underlies late CNS damage after chemotherapy http://dx.doi.org/10.1038/ncpneuro0843 Delayed myelin destruction underlies late CNS damage after chemotherapy

Nature Clinical Practice Neurology 4, 410 (2008). doi:10.1038/ncpneuro0843

]]> Delayed myelin destruction underlies late CNS damage after chemotherapy doi:10.1038/ncpneuro0843 Nature Clinical Practice Neurology 4, 410 (2008) Nature Clinical Practice Neurology 4 8 Research Highlights 410 410 Tarenflurbil slows decline in patients with mild Alzheimer disease http://dx.doi.org/10.1038/ncpneuro0844 Tarenflurbil slows decline in patients with mild Alzheimer disease

Nature Clinical Practice Neurology 4, 410 (2008). doi:10.1038/ncpneuro0844

]]> Tarenflurbil slows decline in patients with mild Alzheimer disease doi:10.1038/ncpneuro0844 Nature Clinical Practice Neurology 4, 410 (2008) Nature Clinical Practice Neurology 4 8 Research Highlights 410 411 Time-dependent protection against dementia by some NSAIDs http://dx.doi.org/10.1038/ncpneuro0845 Time-dependent protection against dementia by some NSAIDs

Nature Clinical Practice Neurology 4, 411 (2008). doi:10.1038/ncpneuro0845

]]> Time-dependent protection against dementia by some NSAIDs doi:10.1038/ncpneuro0845 Nature Clinical Practice Neurology 4, 411 (2008) Nature Clinical Practice Neurology 4 8 Research Highlights 411 411 Red flags in children who present with headache—how to recognize a serious problem http://dx.doi.org/10.1038/ncpneuro0851 Red flags in children who present with headache—how to recognize a serious problem

Nature Clinical Practice Neurology 4, 412 (2008). doi:10.1038/ncpneuro0851

Author: Donald W Lewis

]]> Red flags in children who present with headache—how to recognize a serious problem Donald W Lewis doi:10.1038/ncpneuro0851 Nature Clinical Practice Neurology 4, 412 (2008) 2008-06-10 Nature Clinical Practice Neurology 2008-06-10 4 8 Practice Point 412 413 Optimizing neuropathic pain pharmacotherapy: add on or switch over? http://dx.doi.org/10.1038/ncpneuro0836 Optimizing neuropathic pain pharmacotherapy: add on or switch over?

Nature Clinical Practice Neurology 4, 414 (2008). doi:10.1038/ncpneuro0836

Author: Ian Gilron

]]> Optimizing neuropathic pain pharmacotherapy: add on or switch over? Ian Gilron doi:10.1038/ncpneuro0836 Nature Clinical Practice Neurology 4, 414 (2008) 2008-06-17 Nature Clinical Practice Neurology 2008-06-17 4 8 Practice Point 414 415 Tissue plasminogen activator for acute ischemic stroke—is it for the elderly? http://dx.doi.org/10.1038/ncpneuro0835 Tissue plasminogen activator for acute ischemic stroke—is it for the elderly?

Nature Clinical Practice Neurology 4, 416 (2008). doi:10.1038/ncpneuro0835

Author: Robert J Wityk

]]> Tissue plasminogen activator for acute ischemic stroke—is it for the elderly? Robert J Wityk doi:10.1038/ncpneuro0835 Nature Clinical Practice Neurology 4, 416 (2008) 2008-06-17 Nature Clinical Practice Neurology 2008-06-17 4 8 Practice Point 416 417 Antipsychotics for aggressive behavior in patients with intellectual disability—an acceptable standard of care? http://dx.doi.org/10.1038/ncpneuro0850 Antipsychotics for aggressive behavior in patients with intellectual disability—an acceptable standard of care?

Nature Clinical Practice Neurology 4, 418 (2008). doi:10.1038/ncpneuro0850

Authors: Elaine Tierney & L Eugene Arnold

]]> Antipsychotics for aggressive behavior in patients with intellectual disability—an acceptable standard of care? Elaine Tierney L Eugene Arnold doi:10.1038/ncpneuro0850 Nature Clinical Practice Neurology 4, 418 (2008) 2008-06-24 Nature Clinical Practice Neurology 2008-06-24 4 8 Practice Point 418 419 Cognitive impairment after mild traumatic brain injury—the value of memory testing http://dx.doi.org/10.1038/ncpneuro0866 Cognitive impairment after mild traumatic brain injury—the value of memory testing

Nature Clinical Practice Neurology 4, 420 (2008). doi:10.1038/ncpneuro0866

Author: David J Sharp

]]> Cognitive impairment after mild traumatic brain injury—the value of memory testing David J Sharp doi:10.1038/ncpneuro0866 Nature Clinical Practice Neurology 4, 420 (2008) 2008-07-22 Nature Clinical Practice Neurology 2008-07-22 4 8 Practice Point 420 421 Chronic migraine: (when) should we measure CSF pressure? http://dx.doi.org/10.1038/ncpneuro0864 Chronic migraine: (when) should we measure CSF pressure?

Nature Clinical Practice Neurology 4, 422 (2008). doi:10.1038/ncpneuro0864

Author: Koen Paemeleire

]]> Chronic migraine: (when) should we measure CSF pressure? Koen Paemeleire doi:10.1038/ncpneuro0864 Nature Clinical Practice Neurology 4, 422 (2008) 2008-07-08 Nature Clinical Practice Neurology 2008-07-08 4 8 Practice Point 422 423 Is deep brain stimulation neuroprotective if applied early in the course of PD? http://dx.doi.org/10.1038/ncpneuro0848 This Viewpoint contributes to the topical debate on the therapeutic benefits of deep brain stimulation in Parkinson's disease (PD). The authors argue that there is more to this treatment approach than just providing symptomatic benefits, and suggest that it may actually become the first therapy proven to slow the progression of PD. Is deep brain stimulation neuroprotective if applied early in the course of PD?

Nature Clinical Practice Neurology 4, 424 (2008). doi:10.1038/ncpneuro0848

Authors: P David Charles, Chandler E Gill, Thomas L Davis, Peter E Konrad & Alim-Louis Benabid

]]> Is deep brain stimulation neuroprotective if applied early in the course of PD? P David Charles Chandler E Gill Thomas L Davis Peter E Konrad Alim-Louis Benabid doi:10.1038/ncpneuro0848 Nature Clinical Practice Neurology 4, 424 (2008) 2008-07-01 Nature Clinical Practice Neurology 2008-07-01 4 8 Viewpoint 424 426 Cancer stem cells and glioma http://dx.doi.org/10.1038/ncpneuro0862 In spite of recent advances in surgical and medical therapies, the prognosis for patients diagnosed with the high-grade glioma glioblastoma multiforme remains poor. In this Review, Das et al. present evidence that the resistance of these tumors to current therapies is attributable to a small subpopulation of cancer stem cells, and they consider potential new therapeutic strategies that specifically target this cell population. Cancer stem cells and glioma

Nature Clinical Practice Neurology 4, 427 (2008). doi:10.1038/ncpneuro0862

Authors: Sunit Das, Maya Srikanth & John A Kessler

]]> Cancer stem cells and glioma Sunit Das Maya Srikanth John A Kessler doi:10.1038/ncpneuro0862 Nature Clinical Practice Neurology 4, 427 (2008) 2008-07-15 Nature Clinical Practice Neurology 2008-07-15 4 8 Review 427 435 The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders http://dx.doi.org/10.1038/ncpneuro0847 Desynchronization of circadian rhythms is a common occurrence in individuals presenting with sleep disorders. In this Review, Pandi-Perumal et al. highlight the roles of light and endogenous melatonin in the synchronization of sleep–wake rhythms and rest–activity cycles with the light–dark cycle, and they discuss how light therapy and exogenous melatonin might be used to treat circadian rhythm sleep disorders. The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders

Nature Clinical Practice Neurology 4, 436 (2008). doi:10.1038/ncpneuro0847

Authors: Seithikurippu R Pandi-Perumal, Ilya Trakht, D Warren Spence, Venkataramanujan Srinivasan, Yaron Dagan & Daniel P Cardinali

]]> The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders Seithikurippu R Pandi-Perumal Ilya Trakht D Warren Spence Venkataramanujan Srinivasan Yaron Dagan Daniel P Cardinali doi:10.1038/ncpneuro0847 Nature Clinical Practice Neurology 4, 436 (2008) 2008-07-15 Nature Clinical Practice Neurology 2008-07-15 4 8 Review 436 447 A case of locked-in syndrome complicated by central deafness http://dx.doi.org/10.1038/ncpneuro0823 This Case Study describes a 54-year-old man who developed anarthria and quadriplegia in the context of a brainstem stroke. Normal performance on neuropsychological measures administered nonverbally and failure to activate auditory cortices on functional MRI led to a diagnosis of locked-in-syndrome complicated by central deafness. A case of locked-in syndrome complicated by central deafness

Nature Clinical Practice Neurology 4, 448 (2008). doi:10.1038/ncpneuro0823

Authors: Colette M Smart, Joseph T Giacino, Tara Cullen, Diana Rodriguez Moreno, Joy Hirsch, Nicholas D Schiff & Martin Gizzi

]]> A case of locked-in syndrome complicated by central deafness Colette M Smart Joseph T Giacino Tara Cullen Diana Rodriguez Moreno Joy Hirsch Nicholas D Schiff Martin Gizzi doi:10.1038/ncpneuro0823 Nature Clinical Practice Neurology 4, 448 (2008) 2008-05-27 Nature Clinical Practice Neurology 2008-05-27 4 8 Case Study 448 453 Mapping the progression of progranulin-associated frontotemporal lobar degeneration http://dx.doi.org/10.1038/ncpneuro0869 This Case Study describes in detail a case of progranulin-associated frontotemporal lobar degeneration (FTLD). The patient was initially asymptomatic, but developed progressive brain atrophy and deficits on neuropsychological testing before the clinical onset of cognitive impairment. The authors use this case as a springboard to discuss advances in the genetics of FTLD with an emphasis on the importance of serial cognitive testing and neuroimaging. Mapping the progression of progranulin-associated frontotemporal lobar degeneration

Nature Clinical Practice Neurology 4, 455 (2008). doi:10.1038/ncpneuro0869

Authors: Jonathan D Rohrer, Jason D Warren, Josephine Barnes, Simon Mead, Jonathan Beck, Tracey Pepple, Richard Boyes, Rohani Omar, John Collinge, John M Stevens, Elizabeth K Warrington, Martin N Rossor & Nick C Fox

]]> Mapping the progression of progranulin-associated frontotemporal lobar degeneration Jonathan D Rohrer Jason D Warren Josephine Barnes Simon Mead Jonathan Beck Tracey Pepple Richard Boyes Rohani Omar John Collinge John M Stevens Elizabeth K Warrington Martin N Rossor Nick C Fox doi:10.1038/ncpneuro0869 Nature Clinical Practice Neurology 4, 455 (2008) 2008-07-22 Nature Clinical Practice Neurology 2008-07-22 4 8 Case Study 455 460 Demystifying neurology: preventing 'neurophobia' among medical students http://dx.doi.org/10.1038/ncpneuro0849 Medical students tend to perceive neurology as one of the most difficult medical specialties, and practicing doctors often feel ill-prepared to handle disorders of the nervous system. Lim and Seet believe that the key to solving this problem is to simplify the subject at medical school. In this Training Matters article, they outline neurology teaching approaches that have been adopted at the National University of Singapore. Demystifying neurology: preventing 'neurophobia' among medical students

Nature Clinical Practice Neurology 4, 462 (2008). doi:10.1038/ncpneuro0849

Authors: Erle CH Lim & Raymond CS Seet

]]> Demystifying neurology: preventing 'neurophobia' among medical students Erle CH Lim Raymond CS Seet doi:10.1038/ncpneuro0849 Nature Clinical Practice Neurology 4, 462 (2008) 2008-07-01 Nature Clinical Practice Neurology 2008-07-01 4 8 Training Matters 462 463