Endogenous digitalis: pathophysiologic roles and therapeutic applications

doi:doi:10.1038/ncpneph0848

Nature Clinical Practice Nephrology (2008) 4, 378-392
doi:10.1038/ncpneph0848
Received 21 January 2008 | Accepted 29 April 2008 | Published online: 10 June 2008

Endogenous digitalis: pathophysiologic roles and therapeutic applications

Alexei Y Bagrov* and Joseph I Shapiro

Correspondence *Laboratory of Cardiovascular Science, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA

Email bagrova@mail.nih.gov

Interest in endogenous digitalis-like factors or 'cardiotonic steroids' has increased as a result of the identification of such factors in humans and the delineation of a mechanism by which these hormones signal through the sodium/potassium-transporting ATPase. The authors of this Review, who have both spent more than 20 years conducting research on this topic, examine the role of endogenous cardiotonic steroids in the pathophysiology of renal and cardiovascular disease. They also highlight potential therapeutic strategies involving modulation of cardiotonic steroids.

Full text of this article is available with one of the following:

Membership of the International Society of Nephrology. If already a member, please login. If not please join the Society now
Personal subscription Purchase your own personal subscription to this journal. Already a subscriber? Please login for immediate access.
7 day single article pass for US$32 In order to purchase this article you must be a registered user. Please register or login above.
Site licence Learn more about institutional site licences

Current Subscribers

Please log in to access the full text article using the login box at the top of the page.

Top

Review

Endogenous digitalis: pathophysiologic roles and therapeutic applications

MORE ARTICLES LIKE THIS

NEWS AND VIEWS

RESEARCH

Extra navigation

ARTICLE NAVIGATION - ARTICLE TOOLS

ISSUE NAVIGATION - THIS ISSUE

Main navigation

Resources