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Nature Clinical Practice Nephrology (2008) 4, 298-299
doi:10.1038/ncpneph0802  
Received 1 February 2008 | Accepted 19 February 2008 | Published online: 8 April 2008

Early steroid treatment for drug-induced acute interstitial nephritis

Steven G Coca and Mark A Perazella*

Correspondence *Section of Nephrology, Yale University School of Medicine, FMP 107, 330 Cedar Street, New Haven, CT 60520-8029, USA

Email
 mark.perazella@yale.edu

This article has no abstract so we have provided the first paragraph of the full text.

AIN accounts for 2–10% of all cases of acute kidney injury and approximately 10–27% of all cases of unexplained renal failure. Steroids should be an effective treatment for AIN in humans, as the condition results from cell-mediated immunity. Unfortunately, no randomized controlled trials or prospective studies of steroids in AIN have been performed, which leaves us with only mixed data from retrospective analyses.1, 2, 3, 4

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