Table of contents
June 2008 Volume 4 No 6
Editorial
Research Highlights
Combining low-sodium diet and diuretic maximizes antiproteinuric efficacy of RAAS blockade
290Absence of Oxalobacter formigenes is associated with formation of kidney stones
290Immunization against angiotensin II can reduce ambulatory blood pressure
290Rituximab is effective against lupus nephritis in children
291Low blood pressure does protect against stroke in CKD
291Success for renal tubule cell assist device in phase II trial for acute kidney injury
292Restored live-donor kidneys provide new source of organs for transplantation
292Patients with AA nephropathy are at high risk of late-onset bladder carcinoma
293Colorectal cancer screening in renal transplant recipients is not always cost-effective
293Nocturnal hemodialysis might improve fertility of women on renal replacement therapy
293Kidney transplantation as initial renal replacement therapy for end-stage renal disease
294Practice Points
Use of intravenous sodium bicarbonate might increase the risk of contrast nephropathy
296doi:10.1038/ncpneph0805 | Full Text | PDF (180K)
Early steroid treatment for drug-induced acute interstitial nephritis
298doi:10.1038/ncpneph0802 | Full Text | PDF (177K)
Adapting the Modification of Diet in Renal Disease equation for Japanese patients
300doi:10.1038/ncpneph0783 | Full Text | PDF (176K)
Is low-dose sevelamer administration a cost-effective phosphate-binding strategy in patients on peritoneal dialysis?
302doi:10.1038/ncpneph0767 | Full Text | PDF (176K)
Should hepatitis C virus infection be a contraindication to renal transplantation?
304doi:10.1038/ncpneph0801 | Full Text | PDF (180K)
Early use of renin–angiotensin–aldosterone system inhibitors after renal transplantation
306doi:10.1038/ncpneph0808 | Full Text | PDF (174K)
Viewpoints
Can biologic nanoparticles initiate nephrolithiasis?
308In the late 1990s, a series of papers described the isolation and propagation of calcified, nanometer-sized structures from calf serum and diseased tissues. These findings prompted researchers at the Mayo Clinic, Rochester, MN to investigate the possibility that transmissible biologic nanoparticles could be responsible for pathologic calcification in the kidneys and blood vessels. Here, a member of the Mayo group summarizes the research to date in this exciting field.
doi:10.1038/ncpneph0794 | Full Text | PDF (175K)
Cardiorenal and renocardiac syndromes: the need for a comprehensive classification and consensus
310The authors of this Viewpoint argue that the currently used definitions of cardiorenal syndrome fail to take into account the complex bidirectional nature of the relationship between the heart and kidneys. They propose a new classification of the condition, comprising five subtypes that are distinguished on the basis of the primary and secondary pathology and its chronology. Examples of each subtype are provided.
doi:10.1038/ncpneph0803 | Full Text | PDF (179K)
Reviews
Renal tract malformations: perspectives for nephrologists
312Congenital anomalies of the kidneys and/or lower urinary tract are the major cause of childhood end-stage renal disease, and they can also present in adulthood. Kerecuk et al. summarize the anatomical and histological features of renal tract malformations, the best approaches to prenatal and postnatal diagnosis of these conditions, and the influence of genetic and environmental factors in their etiology. The utility of therapeutic intervention is also considered.
doi:10.1038/ncpneph0807 | Full Text | PDF (524K)
Recommendations and guidelines for the diagnosis and treatment of Fabry nephropathy in adults
327In this Review, participants in the 7th International Fabry Nephropathy Roundtable, which was convened in Barcelona, Spain in June 2007, propose guidelines and recommendations for the diagnosis and management of Fabry nephropathy in adults. The roles of enzyme replacement and antiproteinuric therapy are emphasized. The authors suggest that these organ-specific recommendations could have a greater impact on clinical practice than general Fabry disease guidelines.
doi:10.1038/ncpneph0806 | Full Text | PDF (416K)
Breast cancer screening in women with chronic kidney disease: the unrecognized effects of metastatic soft-tissue calcification
337Patients with chronic kidney disease are known to develop metastatic soft-tissue calcification in tissues including the breast. Such calcifications in women could pose a problem for interpretation of mammograms. Authors from Staten Island University Hospital, NY review the available data on the prevalence and types of breast calcifications in women with chronic kidney disease, and discuss the utility of mammography in this setting.
doi:10.1038/ncpneph0804 | Full Text | PDF (251K)
Case Study
Portal vein thrombosis as the first sign of nephrotic syndrome
342Venous thrombosis is a common complication of nephrotic syndrome, and most often occurs in the renal veins or in the veins of the lower limbs. Portal vein thrombosis is quite uncommon in patients with nephrotic syndrome, and usually only occurs during treatment or recurrence of the condition. In this Case Study, Sun and Xu present a 52-year-old man in whom portal vein thrombosis was the first sign of nephrotic syndrome.
doi:10.1038/ncpneph0810 | Full Text | PDF (304K)
