Even partial remission of proteinuria is associated with better renal outcome in patients with IgA nephropathy
Ryohei Yamamoto* and Enyu Imai
Correspondence *Osaka University Graduate School of Medicine, Department of Nephrology, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Email jackosk@medone.med.osaka-u.ac.jp
This article has no abstract so we have provided the first paragraph of the full text.
Primary IgA nephropathy is the most common type of primary glomerulonephritis in the world. Approximately 20–30% of affected patients develop ESRD within 20–25 years of presentation.1 Many cohort studies have identified the baseline level of proteinuria as a major prognostic factor in IgA nephropathy; proteinuria can, however, be modified by therapeutic agents such as corticosteroids and blockers of the renin–angiotensin–aldosterone system. Several studies have demonstrated that the level of proteinuria at one year after therapeutic intervention is an even more potent predictor of renal outcome than is baseline proteinuria.2 Unfortunately, little information is available about the level of proteinuria that should be targeted during follow-up in order to prevent progression of IgA nephropathy and of chronic kidney disease (CKD).
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