Histological features of renal allograft biopsies in noncompliant patients
This article has no abstract so we have provided the first paragraph of the full text.
Long-term graft survival requires lifelong immunosuppression, but noncompliance is high among renal transplant recipients. 'Swinging' between underdosing and overdosing of medication causes high variability in calcineurin-inhibitor trough levels, and has been shown by Lerut's group to lead to acute cellular rejection and humoral rejection more than 1 year after transplantation. These investigators have now retrospectively studied the same patient cohort and identified several features of noncompliance in acute cellular rejection biopsy tissue sampled late in the post-transplantation period.
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