Does hemolytic uremic syndrome differ from thrombotic thrombocytopenic purpura?
Fadi Fakhouri* and Véronique Frémeaux-Bacchi
Correspondence *Hôpital Necker-Enfants Malades, Service de Néphrologie Adultes, 149–161 rue de Sèvres, Paris cedex 15, 75743, France
Email fadi.fakhouri@nck.aphp.fr
The difficulties that are inherent in the differential diagnosis of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura are a function of the overlap in presenting features. The authors of this Review assert that patient management could be more usefully directed by basing diagnosis on recently elucidated pathogenic mechanisms. To that end, they discuss the involvement of deficiencies in metalloprotease ADAMTS13, and dysfunctional complement proteins.
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