A droplet of water

Long-term health outcomes associated with hydration status

  • Natalia I. Dmitrieva
  • Manfred Boehm
  • Sofia Enhörning
Review Article

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Volume 20 Issue 5
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  • Webinar advertisement

    Watch the recording of our webinar on "Digital Determinants of Health: AI and the need for equity-focused innovation in digital health" with Leo Celi and Kianoush Kashani.

  • A toolbox

    A series of articles that aim to explore the tools and techniques that are improving our understanding of renal development, physiology and disease mechanisms as well as contributing to advances in the screening, diagnosis and management of kidney diseases.

  • A kidney puzzle

    This Focus issue examines how tackling the three dimensions of sustainable development — social, economic and environmental — is essential to improving global kidney health.

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Latest Reviews & Analysis

    • A new study describes the development of proteomics-based ageing clocks that calculate the biological age of specific organs and define features of extreme ageing associated with age-related diseases. Their findings support the notion that plasma proteins can be used to monitor the ageing rates of specific organs and disease progression.

      • Khaoula Talbi
      • Anette Melk
      News & Views

    • This Review outlines the roles of innate and adaptive immune cells in hypertension. The authors discuss the mechanisms and important properties of immune cells that contribute to hypertension pathogenesis, such as memory and plasticity.

      • Bianca A. Nguyen
      • Matthew R. Alexander
      • David G. Harrison
      Review Article

    • Calcium reabsorption along the nephron is essential for calcium homeostasis and whole-body electrolyte balance. Here, Staruschenko et al. highlight signalling pathways and molecules involved in renal calcium handling in health and disease, and discuss progress in the integration of systems-level and molecular understanding of calcium transport and regulation.

      • Alexander Staruschenko
      • R. Todd Alexander
      • Daria V. Ilatovskaya
      Review Article

    • This Review describes parallels in the injury mechanisms that underlie acute kidney injury, chronic kidney disease and allograft injury, and explains how our understanding of the molecular changes that occur in epithelia in the context of kidney disease may contribute to the therapeutic targeting of specific epithelial cell phenotypes for the treatment of transplantation complications.

      • Christian Hinze
      • Svjetlana Lovric
      • Kai M. Schmidt-Ott
      Review Article

    • Despite notable progress in basic, clinical and translational nephrology research in the past 50 years, many challenges remain. In this Review, the authors provide an overview of the current status and future directions in nephrology research and patient care.

      • Carmine Zoccali
      • Francesca Mallamaci
      • Raymond Vanholder
      Review Article

News & Comment

  • Clinical algorithms that are used to guide medical decision-making often include sex as a variable. However, binary considerations of sex and/or gender might introduce bias due to potentially inaccurate assumptions about sex and gender-specific physiology, hormones and exposures. An equity-focused approach to sex and gender is essential when using clinical algorithms to ensure health equity across populations.

    • Dinushika Mohottige
    • Samira Farouk
    • Selma Feldman Witchel
    Comment

  • Clinical trial data suggest that thiazides and thiazide-like drugs could be beneficial for blood-pressure lowering in patients with severe chronic kidney disease. However, prolonged exposure to these photosensitizing drugs could translate into increased risk of squamous cell carcinoma and post-transplant diabetes in the already extremely vulnerable kidney transplant population.

    • Steven Van Laecke
    Comment

  • The prevalence of kidney disease and its associated morbidity and mortality continue to rise. This crisis cannot be tackled unless kidney disease is made a global public health priority.

    Editorial

  • Kidney registries are essential to understanding the burden of kidney disease and facilitating the development of sustainable and effective programs for kidney disease prevention and care. Key barriers to implementation of registries at a global scale include funding and data quality. These issues warrant the attention of the global nephrology community.

    • Christopher H. Grant
    • Fergus J. Caskey
    • Samira Bell
    Comment

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