Our sister journal, Nature Clinical Practice Cardiovascular Medicine, to publish original research

Hannah Camm and Suzanne J Farley

doi:10.1038/ncpneph0639 | Full Text | PDF (129K)

Primary aldosteronism: the case against screening

Paul Padfield

This, the first of two opposing Viewpoints, sets out the arguments against screening for primary aldosteronism. The author, from the Western General Hospital in Edinburgh, UK, asserts that the majority of individuals with a high aldosterone:renin ratio have a normal plasma aldosterone level. Physicians should, therefore, focus on optimizing the excretion of salt and water in hypertensive patients rather than on expensive tests to detect an aldosterone-secreting adenoma.

doi:10.1038/ncpneph0625 | Full Text | PDF (160K)

Primary aldosteronism: the case for screening

Richard D Gordon and Michael Stowasser

In the second of two opposing Viewpoints, these authors from the Greenslopes and Princess Alexandra Hospital Hypertension Units in Brisbane, Australia, describe why, who, and how they screen for primary aldosteronism. They argue that diagnosing (using a stepwise selective approach) and curing or specifically treating aldosterone excess is good for the patient and inexpensive compared with potentially lifelong and less-effective nonspecific antihypertensive therapy.

doi:10.1038/ncpneph0626 | Full Text | PDF (161K)

High risk of stroke events in patients with kidney dysfunction

doi:10.1038/ncpneph0580 | Full Text | PDF (102K)

CKD as a global health problem: KDIGO position statement

doi:10.1038/ncpneph0607 | Full Text | PDF (102K)

Children with a solitary kidney should avoid riding dirt bikes and all-terrain vehicles

doi:10.1038/ncpneph0619 | Full Text | PDF (114K)

Presentation and progression of atypical HUS varies with type of complement-gene mutation

doi:10.1038/ncpneph0603 | Full Text | PDF (105K)

Systematic review of ANCA-associated vasculitis treatments

doi:10.1038/ncpneph0606 | Full Text | PDF (115K)

Cost-effectiveness of management strategies for renal artery stenosis

doi:10.1038/ncpneph0589 | Full Text | PDF (105K)

Stoke comorbidity grade predicts survival in ESRD patients on non-dialytic treatment

doi:10.1038/ncpneph0618 | Full Text | PDF (117K)

Outcomes of access procedures at a high-volume outpatient vascular access center

doi:10.1038/ncpneph0577 | Full Text | PDF (117K)

Hitting K/DOQI targets—except for blood pressure—reduces mortality in HD patients

doi:10.1038/ncpneph0602 | Full Text | PDF (107K)

Antibiotic locks not effective against S. aureus catheter-related bacteremia

doi:10.1038/ncpneph0608 | Full Text | PDF (107K)

CRRT not superior to IRRT in hemodynamically stable patients with acute renal failure

doi:10.1038/ncpneph0588 | Full Text | PDF (115K)

Intensive insulin therapy associated with reduced risk of AKI in critically ill adults

doi:10.1038/ncpneph0604 | Full Text | PDF (103K)

High initial tacrolimus dosage recommended in patients switched from ciclosporin

doi:10.1038/ncpneph0590 | Full Text | PDF (105K)

Body-weight-adjusted mycophenolate mofetil doses in Asian renal transplant recipients

doi:10.1038/ncpneph0605 | Full Text | PDF (105K)

Diagnosis of distal renal tubular acidosis: use of furosemide plus fludrocortisone versus ammonium chloride

George J Schwartz

doi:10.1038/ncpneph0596 | Full Text | PDF (167K)

Eprodisate slows the progression of renal disease in patients with AA amyloidosis

Andrew D Rule and Nelson Leung

doi:10.1038/ncpneph0615 | Full Text | PDF (165K)

Is angiotensin-converting-enzyme inhibition renoprotective in young patients with IgA nephropathy?

Philip KT Li

doi:10.1038/ncpneph0611 | Full Text | PDF (166K)

Does automated peritoneal dialysis provide better outcomes than continuous ambulatory peritoneal dialysis?

Sydney CW Tang and Kar Neng Lai

doi:10.1038/ncpneph0616 | Full Text | PDF (164K)

Is skin perfusion pressure a useful screening tool for peripheral arterial disease in patients on hemodialysis?

Michael Davis and Sanjay Rajagopalan

doi:10.1038/ncpneph0613 | Full Text | PDF (165K)

A total ischemia time of >24 h does not preclude transplantation of kidneys from non-heartbeating donors

Peter S Veitch and Arunthathi O Mahendran

doi:10.1038/ncpneph0614 | Full Text | PDF (164K)

The new peritoneal dialysis solutions: friends only, or foes in part?

Pieter M ter Wee and Frans J van Ittersum

The bio-incompatible characteristics of standard peritoneal dialysis solutions, such as high glucose concentration and nonphysiologic pH, have spurred the development of a new generation of more-biocompatible solutions. In this overview of available clinical data, the advantages and drawbacks of using fluids that contain amino acids or icodextrin, or that have a neutral pH, are debated. The authors conclude that the new peritoneal dialysis solutions hold great promise for improving ultrafiltration and clinical outcomes.

doi:10.1038/ncpneph0620 | Full Text | PDF (319K)

Mechanisms of Disease: WNK-ing at the mechanism of salt-sensitive hypertension

Chou-Long Huang and Elizabeth Kuo

Members of the WNK family of novel serine/threonine kinases inhibit secretion of potassium from the kidney via ROMK. Potassium deficiency—a common problem of modern diets—promotes potassium retention by upregulating WNK1. In this Review of data from animal and human studies, Huang and Kuo frame the hypothesis that WNK-mediated potassium retention is accompanied by sodium retention, and thereby contributes to the development of salt-sensitive hypertension.

doi:10.1038/ncpneph0638 | Full Text | PDF (391K)