Nature Clinical Practice Nephrology Nature Clinical Practice Nephrology provides physicians with authoritative and timely interpretations of key developments in the field, translating the latest findings into clinical practice. http://www.nature.com/ncpneph/current_issue/ Nature Publishing Group en © 2008 Nature Publishing Group Nature Clinical Practice Nephrology 1745-8323 1745-8331 © 2008 Nature Publishing Group permissions@nature.com Nature Clinical Practice Nephrology http://www.nature.com/includes/rj_globnavimages/ncpneph_logo.gif http://www.nature.com/ncpneph/ Progress in the prevention of chronic kidney disease in Latin America http://dx.doi.org/10.1038/ncpneph0811 Progress in the prevention of chronic kidney disease in Latin America

Nature Clinical Practice Nephrology 4, 233 (2008). doi:10.1038/ncpneph0811

Author: Bernardo Rodríguez-Iturbe

]]> Progress in the prevention of chronic kidney disease in Latin America Bernardo Rodríguez-Iturbe doi:10.1038/ncpneph0811 Nature Clinical Practice Nephrology 4, 233 (2008) Nature Clinical Practice Nephrology 4 5 Editorial 233 233 C-reactive protein is neither a marker nor a mediator of atherosclerosis http://dx.doi.org/10.1038/ncpneph0778 It is widely asserted that C-reactive protein (CRP) is a strong independent predictor of atherothrombotic events, and furthermore that CRP is also a pathogenic mediator of atherosclerosis. Here, the author, who first reported the predictive association of CRP with atherothrombotic events, attempts to correct these misapprehensions. He highlights the lack of a convincing association between CRP values and atherosclerosis burden, the fact that the association between baseline CRP values and coronary heart disease is substantially weaker than originally claimed, the nonspecificity of the CRP response and the flaws of cell culture studies with recombinant CRP. C-reactive protein is neither a marker nor a mediator of atherosclerosis

Nature Clinical Practice Nephrology 4, 234 (2008). doi:10.1038/ncpneph0778

Author: Mark B Pepys

]]> C-reactive protein is neither a marker nor a mediator of atherosclerosis Mark B Pepys doi:10.1038/ncpneph0778 Nature Clinical Practice Nephrology 4, 234 (2008) 2008-03-04 Nature Clinical Practice Nephrology 2008-03-04 4 5 Viewpoint 234 235 Renal artery embolization for the symptomatic treatment of adult polycystic kidney disease http://dx.doi.org/10.1038/ncpneph0779 Reports from Japan indicate that renal artery embolization holds promise for relieving the 'mass effect' symptoms of autosomal dominant polycystic kidney disease. Authors from the University of Maryland School of Medicine compare the safety and efficacy of this procedure with that of the techniques more widely used to relieve the symptoms of autosomal dominant polycystic kidney disease, including nephrectomy, cyst marsupialization and cyst decortication. Renal artery embolization for the symptomatic treatment of adult polycystic kidney disease

Nature Clinical Practice Nephrology 4, 236 (2008). doi:10.1038/ncpneph0779

Authors: Matthew S Bremmer & Stephen C Jacobs

]]> Renal artery embolization for the symptomatic treatment of adult polycystic kidney disease Matthew S Bremmer Stephen C Jacobs doi:10.1038/ncpneph0779 Nature Clinical Practice Nephrology 4, 236 (2008) 2008-03-04 Nature Clinical Practice Nephrology 2008-03-04 4 5 Viewpoint 236 237 The risk of acute macular degeneration is increased in patients with CKD http://dx.doi.org/10.1038/ncpneph0773 The risk of acute macular degeneration is increased in patients with CKD

Nature Clinical Practice Nephrology 4, 238 (2008). doi:10.1038/ncpneph0773

]]> The risk of acute macular degeneration is increased in patients with CKD doi:10.1038/ncpneph0773 Nature Clinical Practice Nephrology 4, 238 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 238 239 Low glomerular filtration rate in the Indian population is apparently physiological http://dx.doi.org/10.1038/ncpneph0776 Low glomerular filtration rate in the Indian population is apparently physiological

Nature Clinical Practice Nephrology 4, 238 (2008). doi:10.1038/ncpneph0776

]]> Low glomerular filtration rate in the Indian population is apparently physiological doi:10.1038/ncpneph0776 Nature Clinical Practice Nephrology 4, 238 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 238 238 Low or high birth weight is associated with CKD only in men http://dx.doi.org/10.1038/ncpneph0792 Low or high birth weight is associated with CKD only in men

Nature Clinical Practice Nephrology 4, 238 (2008). doi:10.1038/ncpneph0792

]]> Low or high birth weight is associated with CKD only in men doi:10.1038/ncpneph0792 Nature Clinical Practice Nephrology 4, 238 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 238 238 Neurotoxicity and death after treatment with cefepime in patients with kidney failure http://dx.doi.org/10.1038/ncpneph0772 Neurotoxicity and death after treatment with cefepime in patients with kidney failure

Nature Clinical Practice Nephrology 4, 239 (2008). doi:10.1038/ncpneph0772

]]> Neurotoxicity and death after treatment with cefepime in patients with kidney failure doi:10.1038/ncpneph0772 Nature Clinical Practice Nephrology 4, 239 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 239 239 Reduction of liver volume by sirolimus in patients with polycystic kidney disease http://dx.doi.org/10.1038/ncpneph0774 Reduction of liver volume by sirolimus in patients with polycystic kidney disease

Nature Clinical Practice Nephrology 4, 239 (2008). doi:10.1038/ncpneph0774

]]> Reduction of liver volume by sirolimus in patients with polycystic kidney disease doi:10.1038/ncpneph0774 Nature Clinical Practice Nephrology 4, 239 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 239 240 Patients with nephrotic syndrome have a high absolute risk of thromboembolic events http://dx.doi.org/10.1038/ncpcardio1169 Patients with nephrotic syndrome have a high absolute risk of thromboembolic events

Nature Clinical Practice Nephrology 4, 240 (2008). doi:10.1038/ncpcardio1169

]]> Patients with nephrotic syndrome have a high absolute risk of thromboembolic events doi:10.1038/ncpcardio1169 Nature Clinical Practice Nephrology 4, 240 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 240 240 Simplifying nutritional screening in patients on hemodialysis http://dx.doi.org/10.1038/ncpneph0793 Simplifying nutritional screening in patients on hemodialysis

Nature Clinical Practice Nephrology 4, 240 (2008). doi:10.1038/ncpneph0793

]]> Simplifying nutritional screening in patients on hemodialysis doi:10.1038/ncpneph0793 Nature Clinical Practice Nephrology 4, 240 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 240 240 Monitoring of carotid atherosclerosis for cardiovascular prognostication in ESRD http://dx.doi.org/10.1038/ncpneph0775 Monitoring of carotid atherosclerosis for cardiovascular prognostication in ESRD

Nature Clinical Practice Nephrology 4, 241 (2008). doi:10.1038/ncpneph0775

]]> Monitoring of carotid atherosclerosis for cardiovascular prognostication in ESRD doi:10.1038/ncpneph0775 Nature Clinical Practice Nephrology 4, 241 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 241 241 Stents and stent grafts for vascular-access stenoses that have failed angioplasty http://dx.doi.org/10.1038/ncpneph0788 Stents and stent grafts for vascular-access stenoses that have failed angioplasty

Nature Clinical Practice Nephrology 4, 241 (2008). doi:10.1038/ncpneph0788

]]> Stents and stent grafts for vascular-access stenoses that have failed angioplasty doi:10.1038/ncpneph0788 Nature Clinical Practice Nephrology 4, 241 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 241 241 Protocol biopsies lead to improved function of living-donor renal allografts http://dx.doi.org/10.1038/ncpneph0789 Protocol biopsies lead to improved function of living-donor renal allografts

Nature Clinical Practice Nephrology 4, 241 (2008). doi:10.1038/ncpneph0789

]]> Protocol biopsies lead to improved function of living-donor renal allografts doi:10.1038/ncpneph0789 Nature Clinical Practice Nephrology 4, 241 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 241 242 Laparoscopic living-donor nephrectomy: shorter operating time for right kidney http://dx.doi.org/10.1038/ncpneph0770 Laparoscopic living-donor nephrectomy: shorter operating time for right kidney

Nature Clinical Practice Nephrology 4, 242 (2008). doi:10.1038/ncpneph0770

]]> Laparoscopic living-donor nephrectomy: shorter operating time for right kidney doi:10.1038/ncpneph0770 Nature Clinical Practice Nephrology 4, 242 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 242 243 UNOS criteria identify candidates for organ donation after cardiac death http://dx.doi.org/10.1038/ncpneph0791 UNOS criteria identify candidates for organ donation after cardiac death

Nature Clinical Practice Nephrology 4, 242 (2008). doi:10.1038/ncpneph0791

]]> UNOS criteria identify candidates for organ donation after cardiac death doi:10.1038/ncpneph0791 Nature Clinical Practice Nephrology 4, 242 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 242 242 Successful induction of immune tolerance in kidney graft recipients http://dx.doi.org/10.1038/ncpneph0771 Successful induction of immune tolerance in kidney graft recipients

Nature Clinical Practice Nephrology 4, 243 (2008). doi:10.1038/ncpneph0771

]]> Successful induction of immune tolerance in kidney graft recipients doi:10.1038/ncpneph0771 Nature Clinical Practice Nephrology 4, 243 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 243 243 Upper gastrointestinal complications increase the risk of renal graft failure http://dx.doi.org/10.1038/ncpneph0790 Upper gastrointestinal complications increase the risk of renal graft failure

Nature Clinical Practice Nephrology 4, 243 (2008). doi:10.1038/ncpneph0790

]]> Upper gastrointestinal complications increase the risk of renal graft failure doi:10.1038/ncpneph0790 Nature Clinical Practice Nephrology 4, 243 (2008) Nature Clinical Practice Nephrology 4 5 Research Highlights 243 243 A new supine anterolateral approach to percutaneous ultrasound-guided renal biopsy http://dx.doi.org/10.1038/ncpneph0769 A new supine anterolateral approach to percutaneous ultrasound-guided renal biopsy

Nature Clinical Practice Nephrology 4, 244 (2008). doi:10.1038/ncpneph0769

Authors: Kevin C Abbott & Fred E Yeo

]]> A new supine anterolateral approach to percutaneous ultrasound-guided renal biopsy Kevin C Abbott Fred E Yeo doi:10.1038/ncpneph0769 Nature Clinical Practice Nephrology 4, 244 (2008) 2008-02-26 Nature Clinical Practice Nephrology 2008-02-26 4 5 Practice Point 244 245 Even partial remission of proteinuria is associated with better renal outcome in patients with IgA nephropathy http://dx.doi.org/10.1038/ncpneph0764 Even partial remission of proteinuria is associated with better renal outcome in patients with IgA nephropathy

Nature Clinical Practice Nephrology 4, 246 (2008). doi:10.1038/ncpneph0764

Authors: Ryohei Yamamoto & Enyu Imai

]]> Even partial remission of proteinuria is associated with better renal outcome in patients with IgA nephropathy Ryohei Yamamoto Enyu Imai doi:10.1038/ncpneph0764 Nature Clinical Practice Nephrology 4, 246 (2008) 2008-02-19 Nature Clinical Practice Nephrology 2008-02-19 4 5 Practice Point 246 247 Reducing morbidity and mortality in incident hemodialysis patients with an early intervention program http://dx.doi.org/10.1038/ncpneph0747 Reducing morbidity and mortality in incident hemodialysis patients with an early intervention program

Nature Clinical Practice Nephrology 4, 248 (2008). doi:10.1038/ncpneph0747

Author: Theodore I Steinman

]]> Reducing morbidity and mortality in incident hemodialysis patients with an early intervention program Theodore I Steinman doi:10.1038/ncpneph0747 Nature Clinical Practice Nephrology 4, 248 (2008) 2008-01-29 Nature Clinical Practice Nephrology 2008-01-29 4 5 Practice Point 248 249 Risk factors for and management of sirolimus-associated pneumonitis in kidney transplant recipients http://dx.doi.org/10.1038/ncpneph0768 Risk factors for and management of sirolimus-associated pneumonitis in kidney transplant recipients

Nature Clinical Practice Nephrology 4, 250 (2008). doi:10.1038/ncpneph0768

Author: Stuart M Flechner

]]> Risk factors for and management of sirolimus-associated pneumonitis in kidney transplant recipients Stuart M Flechner doi:10.1038/ncpneph0768 Nature Clinical Practice Nephrology 4, 250 (2008) 2008-02-26 Nature Clinical Practice Nephrology 2008-02-26 4 5 Practice Point 250 251 Urinary tract infection in the renal transplant patient http://dx.doi.org/10.1038/ncpneph0781 Since the first successful kidney transplantations were performed in the 1950s, understanding of the factors that improve graft outcome has advanced. Nevertheless, post-transplantation urinary tract infections continue to be a source of morbidity and graft failure. This article reviews urinary tract infection in the renal transplant recipient, covering epidemiology, etiology, prevention, presentation, investigations, diagnosis and management. Urinary tract infection in the renal transplant patient

Nature Clinical Practice Nephrology 4, 252 (2008). doi:10.1038/ncpneph0781

Authors: Ruth M de Souza & Jonathon Olsburgh

]]> Urinary tract infection in the renal transplant patient Ruth M de Souza Jonathon Olsburgh doi:10.1038/ncpneph0781 Nature Clinical Practice Nephrology 4, 252 (2008) 2008-03-11 Nature Clinical Practice Nephrology 2008-03-11 4 5 Review 252 264 Primer: strategies for identifying genes involved in renal disease http://dx.doi.org/10.1038/ncpneph0785 Identification of the molecular pathways involved in renal pathophysiology can yield targets for intervention and aid tailored therapy. de Borst and colleagues provide an introduction to the tools that can be used to pinpoint genes involved in renal disease, including gene expression arrays, linkage analysis, association studies and animal models. Examples of genes that have been identified using these techniques are highlighted. Primer: strategies for identifying genes involved in renal disease

Nature Clinical Practice Nephrology 4, 265 (2008). doi:10.1038/ncpneph0785

Authors: Martin H de Borst, Ariela Benigni & Giuseppe Remuzzi

]]> Primer: strategies for identifying genes involved in renal disease Martin H de Borst Ariela Benigni Giuseppe Remuzzi doi:10.1038/ncpneph0785 Nature Clinical Practice Nephrology 4, 265 (2008) 2008-03-25 Nature Clinical Practice Nephrology 2008-03-25 4 5 Review 265 276 A case of fluoxetine-induced syndrome of inappropriate antidiuretic hormone secretion http://dx.doi.org/10.1038/ncpneph0780 Ozturk et al. present the case of a schizophrenic male who developed hyponatremia due to fluoxetine-induced syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and psychogenic polydipsia. The Case Study highlights the need for routine monitoring of electrolyte levels in patients with schizophrenia who are taking selective serotonin (5-HT) reuptake inhibitors such as fluoxetine. A case of fluoxetine-induced syndrome of inappropriate antidiuretic hormone secretion

Nature Clinical Practice Nephrology 4, 278 (2008). doi:10.1038/ncpneph0780

Authors: Savas Ozturk, Ekmel Burak Ozsenel, Rumeyza Kazancioglu & Aydin Turkmen

]]> A case of fluoxetine-induced syndrome of inappropriate antidiuretic hormone secretion Savas Ozturk Ekmel Burak Ozsenel Rumeyza Kazancioglu Aydin Turkmen doi:10.1038/ncpneph0780 Nature Clinical Practice Nephrology 4, 278 (2008) 2008-03-04 Nature Clinical Practice Nephrology 2008-03-04 4 5 Case Study 278 282 A case of polyomavirus-associated nephropathy presenting late after transplantation http://dx.doi.org/10.1038/ncpneph0784 Polyomavirus-associated nephropathy (PVAN), an important cause of allograft failure in renal transplant recipients, is usually diagnosed within 12 months of renal transplantation. Bansal et al. present a case of PVAN that developed more than 80 months after transplantation, however, highlighting the fact that PVAN can occur late after transplantation and should be considered in any renal transplant recipient who experiences a change in renal function. A case of polyomavirus-associated nephropathy presenting late after transplantation

Nature Clinical Practice Nephrology 4, 283 (2008). doi:10.1038/ncpneph0784

Authors: Shweta Bansal, M Scott Lucia & Alexander Wiseman

]]> A case of polyomavirus-associated nephropathy presenting late after transplantation Shweta Bansal M Scott Lucia Alexander Wiseman doi:10.1038/ncpneph0784 Nature Clinical Practice Nephrology 4, 283 (2008) 2008-03-11 Nature Clinical Practice Nephrology 2008-03-11 4 5 Case Study 283 287