Collections: Secondary hyperparathyroidism
Featured Articles | Research Highlights | Practice Points | Reviews | Original Research | Correspondence | Web Links
Welcome to the Nature Clinical Practice Nephrology collection on hyperparathyroidism secondary to kidney disease. This collection brings together articles published by Nature Publishing Group in the past 2 years, with a focus on clinical management of this common disorder. Most patients with hyperparathyroidism secondary to kidney failure are managed pharmacologically; evidence for and against available drug treatments is presented and controversies debated. All articles in this collection are available for free in November 2006.
Featured Article
Regulation of parathyroid hormone synthesis and secretion
Justin Silver and Ronen Levi
A comprehensive summary of recent insights into how calcium, phosphorous and vitamin D influence parathyroid hormone in hyperparathyroidism secondary to chronic renal failure. This Review highlights how these novel findings might contribute to the development of new therapeutic options.
Featured Article
Drug Insight: renal indications of calcimimetics
Irina Shahapuni et al.
This Review focuses on the role of drugs such as cinacalcet in the treatment of uremic secondary hyperparathyroidism. Other indications for calcimimetic drugs, such as predialysis secondary hyperparathyroidism and hypercalcemic hyperparathyroidism following kidney transplantation, are also discussed.
Research Highlights
Many patients don't reach targets despite implementation of latest bone disease guidelines
Nature Clinical Practice Nephrology 2, 471 (01 Sep 2006)
Practice Points
Does sevelamer have greater skeletal benefit than calcium carbonate in children with secondary hyperparathyroidism?
Nature Clinical Practice Nephrology 2, 130-131 (01 Mar 2006)
Reviews
Regulation of PTH synthesis and secretion relevant to the management of secondary hyperparathyroidism in chronic kidney disease
Kidney International 67, S8-S12 (01 Jun 2005)
doi:10.1111/j.1523-1755.2005.09501.x | Abstract | Full Text | PDF
An introduction to phosphate binders for the treatment of hyperphosphatemia in patients with chronic kidney disease
Kidney International 68, S2-S6 (01 Jul 2005)
doi:10.1111/j.1523-1755.2005.00448.x | Abstract | Full Text | PDF
Phosphate binder therapy for attainment of K/DOQI™ bone metabolism guidelines
Kidney International 68, S7-S14 (01 Jul 2005)
doi:10.1111/j.1523-1755.2005.00449.x | Abstract | Full Text | PDF
Drug Insight: renal indications of calcimimetics
Nature Clinical Practice Nephrology 2, 316-325 (01 Jun 2006)
Reappraisal of 2003 NKF-K/DOQI guidelines for management of hyperparathyroidism in chronic kidney disease patients
Nature Clinical Practice Nephrology 2, 326-336 (01 Jun 2006)
Original Research
Achieving NKF-K/DOQI™ bone metabolism and disease treatment goals with cinacalcet HCl
Kidney International 67, 760-771 (01 Feb 2005)
doi:10.1111/j.1523-1755.2005.67139.x | Abstract | Full Text | PDF
Serum fibroblast growth factor-23 levels predict the future refractory hyperparathyroidism in dialysis patients
Kidney International 67, 1171-1178 (01 Mar 2005)
doi:10.1111/j.1523-1755.2005.00184.x | Abstract | Full Text | PDF
Pretreatment serum FGF-23 levels predict the efficacy of calcitriol therapy in dialysis patients
Kidney International 67, 1120-1125 (01 Mar 2005)
doi:10.1111/j.1523-1755.2005.00178.x | Abstract | Full Text | PDF
Progression of secondary hyperparathyroidism involves deregulation of genes related to DNA and RNA stability
Kidney International 67, 2267-2279 (01 Jun 2005)
doi:10.1111/j.1523-1755.2005.00330.x | Abstract | Full Text | PDF
Calcimimetics: A new tool for management of hyperparathyroidism and renal osteodystrophy in patients with chronic kidney disease
Kidney International 67, S33-S36 (01 Jun 2005)
doi:10.1111/j.1523-1755.2005.09505.x | Abstract | Full Text | PDF
Cinacalcet HCl: A novel treatment for secondary hyperparathyroidism in stage 5 chronic kidney disease
Kidney International 68, S24-S28 (01 Jun 2005)
doi:10.1111/j.1523-1755.2005.00451.x | Abstract | Full Text | PDF
Structure of non-(1-84) PTH fragments secreted by parathyroid glands in primary and secondary hyperparathyroidism
Kidney International 68, 998-1007 (01 Sep 2005)
doi:10.1111/j.1523-1755.2005.00493.x | Abstract | Full Text | PDF
Correspondence
Opportunity and cost of sevelamer in dialysis patients
Kidney International 67, 1636 (01 Apr 2005)
doi:10.1111/j.1523-1755.2005.247_5.x | Abstract | Full Text | PDF
Economic impact of sevelamer in patients with ESRD
Kidney International 67, 1636-1637 (01 Apr 2005)
doi:10.1111/j.1523-1755.2005.247_6.x | Abstract | Full Text | PDF
High dialysate calcium may improve the efficacy of calcimimetic treatment in hemodialysis patients with severe secondary hyperparathyroidism
Kidney International 67, 2065 (01 May 2005)
doi:10.1111/j.1523-1755.2005.310_1.x | Abstract | Full Text | PDF
Reply from the Authors
Kidney International 67, 2065-2066 (01 May 2005)
Active vitamin D agents and refractory hyperparathyroidism in dialysis patients
Kidney International 68, 410 (01 Jul 2005)
Reply from the Authors
Kidney International 68, 410-411 (01 Jul 2005)


