Practice Point

Nature Clinical Practice Gastroenterology & Hepatology (2008) 5, 128-129
doi:10.1038/ncpgasthep1026  
Received 24 August 2007 | Accepted 7 November 2007 | Published online: 11 December 2007

How useful is combined chromoendoscopy and endomicroscopy in patients with ulcerative colitis?

Irfan Nawaz and Michael B Wallace*

Correspondence *Division of Gastroenterology, Mayo Clinic, Jacksonville, FL 32224, USA

Email
 wallace.michael@mayo.edu

This article has no abstract so we have provided the first paragraph of the full text.

In the US, 8 new cases of ulcerative colitis are diagnosed per 100,000 people per year.1 The cumulative incidence of neoplasia by disease duration in these patients is 1.5% at 10 years, 7.7% at 20 years, 15.8% at 30 years, 22.7% at 40 years, and 27.5% at 45 years.2 Gastrointestinal societies recommend surveillance colonoscopy in patients with ulcerative colitis with multiple biopsy specimens taken every 1–2 years beginning 8–10 years after the onset of the disease. This process is not only time consuming—if the protocol of taking 2–4 biopsies every 10 cm segment is followed—but flat and multifocal lesions can still be missed.

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