Can NOD2/CARD15 mutations predict intestinal graft-versus-host disease and aid our understanding of Crohn's disease?
Gerhard Rogler* and Ernst Holler
Correspondence *Department of Internal Medicine I, University of Regensburg, Regensburg, 93042, Germany.
Email gerhard.rogler@klinik.uni-regensburg.de
A central role is proposed for the gastrointestinal tract in graft-versus-host disease (GvHD) because the occurrence of NOD2/CARD15 mutations in the gut can predict severe GvHD. These findings could influence current therapeutic strategies for GvHD and Crohn's disease and change our understanding of their pathophysiology.
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