Review

Nature Clinical Practice Gastroenterology & Hepatology (2004) 1, 98-105
doi:10.1038/ncpgasthep0055  
Received 16 August 2004 | Accepted 25 October 2004

Mechanisms of Disease: mechanisms of hepatic fibrosis and therapeutic implications

Scott L Friedman

Correspondence Box 1123, Mount Sinai School of Medicine, 1425 Madison Ave, Room 1170C, New York, NY 10029, USA

Email Scott.Friedman@mssm.edu

Basic research has led to rapid progress in understanding the mechanisms underlying hepatic fibrosis. Fibrogenic hepatic cell types have been characterized, as have general and disease-specific mechanisms. Studies also indicate that hepatic fibrosis is reversible. The impact of this work on clinical practice is that treating hepatic fibrosis is now emerging as a real possibility.

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