Mechanisms of Disease: the role of hepcidin in iron homeostasis|[mdash]|implications for hemochromatosis and other disorders

doi:doi:10.1038/ncpgasthep0019

Nature Clinical Practice Gastroenterology & Hepatology (2004) 1, 39-45
doi:10.1038/ncpgasthep0019

Mechanisms of Disease: the role of hepcidin in iron homeostasis—implications for hemochromatosis and other disorders

Antonello Pietrangelo* and Christian Trautwein

Correspondence *Center for Hemochromatosis, Department of Internal Medicine, University of Modena and Reggio Emilia, Policlinico, Via del Pozzo 71, 41100, Modena, Italy

Email pietrangelo.antonello@unimore.it

Hepcidin is the iron-regulatory hormone that links innate immunity and iron metabolism. Normally, a regulatory feedback loop with circulatory iron controls hepatic hepcidin production. Inflammatory stimuli upregulate hepcidin production, which can lead to anemia. Anemia downregulates hepcidin production. Human disorders associated with inappropriate hepcidin levels include anemia of inflammation and hereditary hemochromatosis.

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Mechanisms of Disease: the role of hepcidin in iron homeostasis—implications for hemochromatosis and other disorders

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