Table of contents
June 2008 Volume 4 No 6
Editorial
Research Highlights
Sons of women with PCOS have an increased risk of developing insulin resistance
302Artificial pancreas is feasible for pediatric patients with type 1 diabetes
302In vivo 
MRI detects trabecular bone changes soon after menopause
302An autosomal-dominant GPR54 mutation implicated in central precocious puberty
303Increased glucose levels and blood pressure in IVF-conceived children
303Diabetes is associated with poor outcomes after bypass surgery
304Novel locus on chromosome 1 involved in LDL cholesterol metabolism
304MicroRNA profiling might improve the diagnostic accuracy of thyroid FNA
305Central adrenal insufficiency is common in children with Prader–Willi syndrome
305VEGF-C associated with advanced tumor stage and nodal metastases in PTC
305New predictive model for complete resolution of hypertension after adrenalectomy
306Development of hyperandrogenemia in women receiving pulsatile GnRH therapy
306Reduction in vertebral fracture risk persists after discontinuation of risedronate
307Practice Points
Once-yearly zoledronate—an effective preventative therapy for new fractures after hip fracture?
308doi:10.1038/ncpendmet0813 | Full Text | PDF (102K)
Evaluation of bilateral laparoscopic adrenalectomy in adrenocorticotropic hormone-dependent Cushing's syndrome
310doi:10.1038/ncpendmet0808 | Full Text | PDF (101K)
Does primary etiology affect outcomes in adults with childhood-onset growth hormone deficiency?
312doi:10.1038/ncpendmet0810 | Full Text | PDF (101K)
Use of plasma chromogranin A and urine fractionated metanephrines to diagnose pheochromocytoma?
314doi:10.1038/ncpendmet0812 | Full Text | PDF (103K)
Does high-trauma fracture increase the risk of subsequent osteoporotic fracture?
316doi:10.1038/ncpendmet0811 | Full Text | PDF (100K)
Diabetic nephropathy—an evaluation of potential risk factors in young patients with type 1 diabetes mellitus
318doi:10.1038/ncpendmet0814 | Full Text | PDF (102K)
Viewpoints
Treatment of impaired glucose tolerance in childhood
320Impaired glucose tolerance is a prediabetic condition that is a major risk factor for subsequent development of type 2 diabetes mellitus. As type 2 diabetes mellitus has become common among obese adolescents, options for the management of children with impaired glucose tolerance are discussed in this Viewpoint.
doi:10.1038/ncpendmet0815 | Full Text | PDF (100K)
Differentiating between body fat and lean mass—how should we measure obesity?
322Patients defined as overweight or obese on the basis of BMI have reduced mortality and cardiovascular risk when compared with their normal-weight counterparts. The authors of this Viewpoint propose that these paradoxical results might reflect how obesity is currently measured and highlight the importance of differentiating between body fat and lean mass.
doi:10.1038/ncpendmet0809 | Full Text | PDF (102K)
Reviews
Long-term effects of pegvisomant in patients with acromegaly
324Achieving biochemical remission and tumor shrinkage in acromegaly can prove difficult despite a range of available therapies. Pegvisomant seems to be useful to attain the former but certain adverse effects have raised concern. This Review rounds up the evidence on the safety and efficacy of this drug, summarizes risks and benefits and suggests therapeutic approaches.
doi:10.1038/ncpendmet0831 | Full Text | PDF (188K)
Prevention of type 1 diabetes: the time has come
334Type 1 diabetes mellitus is a chronic process of many years, during which insulin production slowly decreases. This key feature makes the disease a potential candidate for treatment but also for prevention against symptoms becoming clinically overt. This Review discusses issues of diagnosis and risk stratification, and the development of prevention strategies.
doi:10.1038/ncpendmet0832 | Full Text | PDF (177K)
Late-night salivary cortisol measurement in the diagnosis of Cushing's syndrome
344Cushing's syndrome is no longer considered rare, but making a diagnosis remains challenging. Traditional tests yield variable results. Measurement of late-night serum cortisol levels can deliver excellent sensitivity and specificity but blood samples must be taken during a hospital stay. Here, Carroll et al. put forward the case for late-night salivary cortisol measurement as a simple alternative test.
doi:10.1038/ncpendmet0837 | Full Text | PDF (159K)
Case Study
A patient with MEN1-associated hyperparathyroidism, responsive to cinacalcet
351The patient described in this article had a history of hereditary primary hyperparathyroidism, which is usually treated surgically. When the patient developed a recurrent parathyroid adenoma she refused surgery and in this Case Study the authors describe, for the first time, the use of the calcimimetic cinacalcet in a patient with hereditary primary hyperparathyroidism.
doi:10.1038/ncpendmet0816 | Full Text | PDF (252K)
