Mechanisms of Disease: advanced glycation end-products and their receptor in inflammation and diabetes complications
Shi Fang Yan, Ravichandran Ramasamy and Ann Marie Schmidt*
Correspondence *Division of Surgical Science, Department of Surgery, Columbia University Medical Center, 630 West 168th Street, P&S 17-401, New York, NY 10032, USA
Email ams11@columbia.edu
Injury to the vasculature is an important adverse outcome in diabetes. In this Review, Yan et al. explore how advanced glycation end-products and their main receptor, RAGE, might have roles in the development of diabetes and some of its complications–nephropathy, atherosclerosis and inflammatory response–through activation of inflammatory signaling cascades.
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