Weight loss >10% is required to improve inflammatory marker levels in the obese
This article has no abstract so we have provided the first paragraph of the full text.
Long-term metabolic complications of obesity include low-grade inflammation, characterized by decreased levels of the anti-inflammatory adipokine adiponectin and increased levels of proinflammatory proteins fibrinogen and C-reactive protein (CRP, detected by high-sensitivity assay). Weight loss should improve levels of these markers, but study findings are conflicting. Madsen and colleagues investigated the effect of weight loss on levels of adiponectin, fibrinogen and CRP in a SMOMS substudy (a randomized, controlled trial of the lipase inhibitor orlistat).
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