High IGF-I levels imply active acromegaly even when GH levels are 'normal'
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Biochemical control of acromegaly in noncured patients is usually defined as serum growth hormone (GH) levels <2.0 
g/l, plus normal-for-age serum levels of insulin-like growth factor I (IGF-I). Alexopoulou et al., however, have confirmed reports of discordant IGF-I and GH results in noncured patients with acromegaly: in over one-third of their cohort, one parameter was elevated despite the other being normal.
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