Table of contents
March 2008 Volume 4 No 3
Editorial
Chernobyl and the KI controversy in the United States
117doi:10.1038/ncpendmet0779 | Full Text | PDF (102K)
Viewpoint
Which children with idiopathic short stature should receive growth hormone therapy?
118The use of growth hormone to treat children with idiopathic short stature remains an area of controversy. The author of this Viewpoint discusses the possible etiology of idiopathic short stature, the efficacy and safety of the treatment regimen, and which children with this condition should be selected for therapy.
doi:10.1038/ncpendmet0700 | Full Text | PDF (124K)
Research Highlights
Low bone density as a result of constitutional thinness
120The use of complementary and alternative medicine by patients with osteoporosis
120Increased liver fat content in patients with type 2 diabetes is independent of obesity
120Prevalence and diagnosis of nonclassical congenital adrenal hyperplasia
121Reduced BMD is associated with arterial calcification
121Serum uric acid levels predict mortality in patients with type 2 diabetes
122Food consumed in beverage form independently increases daily energy intake
122Assessing bone fracture risk in association with height loss in the elderly
123Increased BMI affects cancer incidence and mortality
123Tissue-specific regulation of thyroid hormone bioavailability in NTIS
123Radioiodine in thyroid cancer—effects on testicular function
124Optimal antihypertensive therapy in patients with the metabolic syndrome
124Dietary and lifestyle modification could prevent cases of ovulatory disorder infertility
125Practice Points
Is hypopituitarism predictable after traumatic brain injury?
126doi:10.1038/ncpendmet0719 | Full Text | PDF (125K)
Is total thyroidectomy the procedure of choice for low-risk papillary thyroid cancer?
128doi:10.1038/ncpendmet0720 | Full Text | PDF (128K)
Does treatment with 17 
-hydroxyprogesterone caproate increase the risk of gestational diabetes mellitus?
130doi:10.1038/ncpendmet0721 | Full Text | PDF (132K)
Does genetic screening increase detection of familial medullary thyroid cancer in apparently sporadic cases?
132doi:10.1038/ncpendmet0722 | Full Text | PDF (127K)
Can acute administration of pamidronate help to preserve bone mass in children with severe burn injury?
134doi:10.1038/ncpendmet0724 | Full Text | PDF (127K)
Does surgically induced weight loss decrease mortality?
136doi:10.1038/ncpendmet0725 | Full Text | PDF (128K)
The role of fractionated radiotherapy and stereotactic radiosurgery for pituitary adenomas
138doi:10.1038/ncpendmet0746 | Full Text | PDF (129K)
Reviews
Weight loss and metabolic benefits with diets of varying fat and carbohydrate content: separating the wheat from the chaff
140There is a pressing need for diets that are effective, palatable and sustainable. Several diets are available that vary the proportions of macronutrients, and show promise in reducing weight and cardiovascular risk. This article concentrates especially on two such variations—those low in carbohydrates, and those high in monounsaturated fats.
doi:10.1038/ncpendmet0730 | Full Text | PDF (222K)
Reawakened interest in type III iodothyronine deiodinase in critical illness and injury
148Type III iodothyronine deiodinase (D3) is important for thyroid hormone inactivation, but is difficult to detect in normal adult tissue and has therefore been somewhat neglected. This article details studies showing elevated expression in certain tissues during critical illness and tissue injury, which might be significant for normal responses to trauma.
doi:10.1038/ncpendmet0727 | Full Text | PDF (277K)
Mechanisms of Disease: genetic insights into the etiology of type 2 diabetes and obesity
156As detailed here, recent genome-wide scans have identified several novel loci influencing obesity and common forms of diabetes. Such findings may in the future unravel pathways that can be targets for therapy or intervention, and perhaps enable treatments to be tailored to individuals on the basis of their genetic makeup.
doi:10.1038/ncpendmet0723 | Full Text | PDF (221K)
Mechanisms of Disease: using genetically altered mice to study concepts of type 2 diabetes
164This article describes recent findings from genetically engineered murine models of type 2 diabetes, particularly those giving insight into defects in insulin's actions and the relationship between insulin resistance and impaired 
-cell function. These models have the potential to examine specific molecular mechanisms that combine to cause diabetes in humans.
doi:10.1038/ncpendmet0729 | Full Text | PDF (312K)
Case Study
Hormonal therapy in a patient with a delayed diagnosis of Turner's syndrome
173Patients with Turner's syndrome are often diagnosed late. The patient described in this article was diagnosed at the age of 15 years. The use of hormone-replacement therapy as well as growth-promoting therapy are discussed.
doi:10.1038/ncpendmet0747 | Full Text | PDF (235K)
