Tissue-specific regulation of thyroid hormone bioavailability in NTIS
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Little is known of the molecular mechanisms underlying the disruption in thyroid hormone (TH) homeostasis during nonthyroidal illness syndrome (NTIS), or whether this is of overall benefit during illness. Previous studies in humans have focused on samples from dead patients, but now Rodriguez-Perez et al. have characterized gene expression in 13 patients with septic-shock-induced NTIS, compared with that in 17 control patients. Biopsy samples were taken of skeletal muscle and subcutaneous adipose tissue for mRNA expression analysis of several TH-regulating genes.
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