Mechanisms of Disease: using genetically altered mice to study concepts of type 2 diabetes
Derek LeRoith* and Domenico Accili
Correspondence *Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Atran AB4-36, Box 1055, New York, NY 10029-6574, USA
Email derek.leroith@mssm.edu
This article describes recent findings from genetically engineered murine models of type 2 diabetes, particularly those giving insight into defects in insulin's actions and the relationship between insulin resistance and impaired 
-cell function. These models have the potential to examine specific molecular mechanisms that combine to cause diabetes in humans.
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